Eficacia del plasma rico en plaquetas en el rejuvenecimiento facial: una revisión sistemática

IF 1.1 Q4 NURSING

Enfermeria Clinica Pub Date : 2025-09-01 DOI:10.1016/j.enfcli.2024.502161

María José Rodríguez-Castro , Alda Elena Cortés Rodríguez

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引用次数: 0

Abstract

Aim

To evaluate the effects of platelet-rich plasma (PRP) in facial rejuvenation.

Methods

A systematic review was conducted from November 2022 to September 2024. Literature searches were performed in the databases PubMed, CINAHL, SCOPUS, Cuiden and Scielo using the terms platelet rich plasma, rejuvenation, skin, plasma skin regeneration, and platelet rich plasma rejuvenation. Studies published with participants over 18 years old, using exclusively PRP for facial rejuvenation, were selected. Reviews and meta-analyses, as well as studies involving patients with conditions that could affect the treatment, were excluded.

Results

Nine clinical trials and two observational study were included. Clinically, four studies indicated that PRP improved wrinkles and skin texture. Histologically, this substance induced a cascade of growth factors that increased dermal density, reducing wrinkles and improving skin luminosity and hydration. Despite these observations, discrepancies were observed regarding the different application techniques (topical or injected) and doses administered. Adverse effects were rare, including bruising and edema caused by injections and occasionally, papules, scaling, and dryness at the injection site.

Conclusion

Platelet-rich plasma may be effective for facial rejuvenation based on histological results and patient references. However, further studies are needed to determine the most the most appropriate procedure for its administration.

PROSPERO register number: CRD42024513433.

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富血小板血浆在面部年轻化中的有效性：系统综述

目的探讨富血小板血浆（PRP）在面部年轻化中的作用。方法于2022年11月至2024年9月进行系统评价。在PubMed， CINAHL， SCOPUS， Cuiden和Scielo数据库中检索富血小板血浆，年轻化，皮肤，血浆皮肤再生和富血小板血浆年轻化。研究发表的参与者超过18岁，专门使用PRP面部年轻化，被选中。综述和荟萃分析以及涉及可能影响治疗的患者的研究被排除在外。结果纳入9项临床试验和2项观察性研究。临床上，四项研究表明，PRP改善皱纹和皮肤质地。从组织学上讲，这种物质诱导了一系列生长因子，增加了真皮密度，减少了皱纹，改善了皮肤的光泽和水合作用。尽管有这些观察结果，但在不同的应用技术（局部或注射）和施用剂量方面观察到差异。不良反应很少，包括注射引起的瘀伤和水肿，偶尔在注射部位出现丘疹、脱屑和干燥。结论基于组织学结果和患者参考资料，富血小板血浆治疗面部年轻化可能有效。但是，需要进一步的研究来确定最适当的给药程序。普洛斯彼罗注册号：CRD42024513433。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Enfermeria Clinica NURSING-

CiteScore

2.00

自引率

0.00%

发文量

期刊介绍： Enfermería Clínica is a peer-reviewed scientific journal that is a useful and necessary tool for nursing professionals from the different areas of nursing (healthcare, administration, education and research) as well as for healthcare professionals involved in caring for persons, families and the community. It is the only Spanish nursing journal that mainly publishes original research. The aim of the Journal is to promote increased knowledge through the publication of original research and other studies that may help nursing professionals improve their daily practice. This objective is pursued throughout the different sections that comprise the Journal: Original Articles and Short Original Articles, Special Articles, Patient Care and Letters to the Editor. There is also an Evidence-Based Nursing section that includes comments about original articles of special interest written by experts.