Synthesis, characterization, and biological evaluation of Schiff base ligand and their metal complexes: implications for coordination chemistry and biomedical applications

Abstract

“Schiff base Metal Complex” (SBMC) have received increased attention in coordination chemistry for their versatility and promising biomedical applications in the last decade. The target of this research includes the composite, characterization and biological evaluation of “Schiff base Ligand” (SBL) as well as their metal complexes with Mn, Co, Ni, Cu and Zn. By systematically synthesizing these metal complexes and characterising their structural and spectral properties by NMR, FTIR, XRD, SEM, electronic spectra and ESI mass spectrometry, I have gained an understanding of the behaviour of Pd on the semiconductor that provides indications of its nature. Antioxidant, antibacterial and cytotoxicity assays were used to test biological activity with Cu (II) complex having the highest antioxidant activity (85 % inhibition, IC50 = 6 μM) and cytotoxic activity towards MCF7 cancer cells. Mn (II) together with Ni (II) Co (II) and Zn (II) exhibited reasonable biological actions which were detected in their structures. Complex studies showed that Cu (II) exhibited the strongest DNA binding capacity making it an exceptional anticancer agent. Bioactivity in SBMC is largely determined by metal ion species combined with the organic moiety according to the findings of this investigation. Results indicate that Cu (II) and Mn (II) complex shows exceptional potential to address diseases associated with oxidative stress and cancer. The development of new metal-based drugs along with potential biomedical uses of SB complexes benefits from the current jury of SB complexes.