Simultaneous measurement of solubility and diffusion coefficient in partially miscible liquid systems using the liquid-core cylindrical lenses.

Applied optics Pub Date : 2025-09-20 DOI:10.1364/AO.570369
Qing Yue, Yuanfangzhou Wang, Zhiwei Li, Qianlan Liu, Licun Sun
{"title":"Simultaneous measurement of solubility and diffusion coefficient in partially miscible liquid systems using the liquid-core cylindrical lenses.","authors":"Qing Yue, Yuanfangzhou Wang, Zhiwei Li, Qianlan Liu, Licun Sun","doi":"10.1364/AO.570369","DOIUrl":null,"url":null,"abstract":"<p><p>Dissolution and diffusion in partially miscible liquid systems are prevalent physical phenomena. Parameters governing these processes, such as solubility (<i>S</i>) and diffusion coefficient (<i>D</i>), must be accurately measured for applications in biopharmaceuticals, chemical production, and food manufacturing. However, current common measurement methods are often time-consuming, require complex equipment, or lack accuracy, and they cannot measure both parameters simultaneously. In this study, we proposed a real-time optical image feature extraction method that utilizes the refractive-index spatiotemporal resolution capability of a compound liquid-core cylindrical lens to enable simultaneous assessment of <i>S</i> and <i>D</i> in partially miscible liquid systems. The <i>D</i> values of a glyceryl triacetate-water partially miscible system at five different temperature settings were measured using the equal-refractive-index thin-layer method based on the one-dimensional semi-infinite diffusion model, while <i>S</i> values were determined from the width of the image. The measured data at 298 K agreed with results obtained by other methods, confirming the reliability of the experiment and method. This method features a simple experimental setup and convenient operation, demonstrating broad application prospects.</p>","PeriodicalId":101299,"journal":{"name":"Applied optics","volume":"64 27","pages":"8095-8103"},"PeriodicalIF":0.0000,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied optics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1364/AO.570369","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Dissolution and diffusion in partially miscible liquid systems are prevalent physical phenomena. Parameters governing these processes, such as solubility (S) and diffusion coefficient (D), must be accurately measured for applications in biopharmaceuticals, chemical production, and food manufacturing. However, current common measurement methods are often time-consuming, require complex equipment, or lack accuracy, and they cannot measure both parameters simultaneously. In this study, we proposed a real-time optical image feature extraction method that utilizes the refractive-index spatiotemporal resolution capability of a compound liquid-core cylindrical lens to enable simultaneous assessment of S and D in partially miscible liquid systems. The D values of a glyceryl triacetate-water partially miscible system at five different temperature settings were measured using the equal-refractive-index thin-layer method based on the one-dimensional semi-infinite diffusion model, while S values were determined from the width of the image. The measured data at 298 K agreed with results obtained by other methods, confirming the reliability of the experiment and method. This method features a simple experimental setup and convenient operation, demonstrating broad application prospects.

用液芯圆柱透镜同时测量部分混相液体体系中的溶解度和扩散系数。
溶解和扩散是部分混相液体体系中普遍存在的物理现象。控制这些过程的参数,如溶解度(S)和扩散系数(D),必须精确测量用于生物制药、化学生产和食品制造的应用。然而,目前常用的测量方法往往耗时长、设备复杂或精度低,无法同时测量这两个参数。在这项研究中,我们提出了一种实时光学图像特征提取方法,该方法利用复合液芯柱透镜的折射率时空分辨率能力,在部分混相液体系统中同时评估S和D。采用基于一维半无限扩散模型的等折射率薄层法测量了三乙酸甘油-水部分混相体系在五种不同温度下的D值,并根据图像宽度确定了S值。298 K下的实测数据与其他方法的结果一致,证实了实验和方法的可靠性。该方法实验设置简单,操作方便,具有广阔的应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信