Bo-Wen Hou, Zheng Ran, Yi-Tong Li, Jing Zhang, Yong-Qiang Chu, Nadeer M Gharaibeh, Xiao-Ming Li
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引用次数: 0
Abstract
Background: Insulin resistance (IR) plays a critical role in the musculoskeletal metabolic disorders associated with type 2 diabetes mellitus (T2DM).
Aim: To develop multiparametric magnetic resonance imaging (MRI)-derived biomarkers and diagnostic models for non-invasive identification and stratification of IR.
Methods: Parameters of paravertebral muscles and vertebra were evaluated using quantitative chemical shift-encoded MRI and diffusion tensor imaging protocols. Tripartite cohort analyses were conducted through Kruskal-Wallis H tests with post hoc Dunn-Bonferroni correction for MRI-derived metrics. Diagnostic performance for T2DM-IR was assessed after selecting the most significant features through Z-score standardization and multinomial logistic regression models.
Results: This study evaluated 97 subjects (control: 39 subjects, T2DM-IR: 18 subjects, T2DM patients without IR: 40 subjects) using multiparametric MRI protocols. Significant intergroup differences were observed in the cross-sectional area (P = 0.047) and apparent diffusion coefficient (P = 0.027) of the psoas, and the cross-sectional area (P = 0.042) of the erector. More intramyocellular lipid (IMCL) in the psoas (P = 0.001) and erector (P = 0.004) were found in the T2DM-IR group. Multinomial receiver operating characteristic curve analysis demonstrated that IMCL of the erector performed better (area under the curve = 0.838, sensitivity: 0.800, specificity: 0.938) in the diagnosis of T2DM-IR.
Conclusion: IMCL in erector emerges as a highly discriminative metric for T2DM-IR diagnosis. Multiparametric MRI enables non-invasive quantification of early musculoskeletal metabolic injury, providing reliable biomarkers for IR identification and stratification.
期刊介绍：
The WJD is a high-quality, peer reviewed, open-access journal. The primary task of WJD is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of diabetes. In order to promote productive academic communication, the peer review process for the WJD is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJD are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in diabetes. Scope: Diabetes Complications, Experimental Diabetes Mellitus, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, Diabetes, Gestational, Diabetic Angiopathies, Diabetic Cardiomyopathies, Diabetic Coma, Diabetic Ketoacidosis, Diabetic Nephropathies, Diabetic Neuropathies, Donohue Syndrome, Fetal Macrosomia, and Prediabetic State.
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