Early glucocorticoid withdrawal in severe ANCA-associated vasculitis treated with combination cyclophosphamide and rituximab: a single-centre case series.

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Internal Medicine Journal Pub Date : 2025-09-22 DOI:10.1111/imj.70212

Tania Salehi, Karthik Venkataraman, Jarrad Hopkins, John Lau, Philip Clayton, Joanna Tieu, Chen Au Peh

引用次数: 0

Abstract

Glucocorticoid (GC)-related toxicity remains a major challenge in anti-neutrophil cytoplasm antibody-associated vasculitis (AAV). We report five cases of newly diagnosed severe AAV treated with combination cyclophosphamide and rituximab, with the goal of ceasing GCs within 4 weeks. All patients achieved complete remission, with one relapse during follow-up. All remained GC-free at a median follow-up of 12 months. The regimen was well tolerated despite severe renal impairment. These findings support the feasibility of early GC withdrawal in organ-threatening AAV.

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环磷酰胺和利妥昔单抗联合治疗严重anca相关性血管炎的早期糖皮质激素停药：单中心病例系列

糖皮质激素（GC）相关毒性仍然是抗中性粒细胞细胞质抗体相关血管炎（AAV）的主要挑战。我们报告了5例新诊断的严重AAV患者接受环磷酰胺和利妥昔单抗联合治疗，目标是在4周内停止GCs。所有患者均获得完全缓解，随访期间有1例复发。在中位随访12个月时，所有患者均无gc。尽管存在严重的肾脏损害，但该方案耐受性良好。这些发现支持了在危及器官的AAV中早期停用GC的可行性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Internal Medicine Journal 医学-医学：内科

CiteScore

3.50

自引率

4.80%

发文量

600

审稿时长

3-6 weeks

期刊介绍： The Internal Medicine Journal is the official journal of the Adult Medicine Division of The Royal Australasian College of Physicians (RACP). Its purpose is to publish high-quality internationally competitive peer-reviewed original medical research, both laboratory and clinical, relating to the study and research of human disease. Papers will be considered from all areas of medical practice and science. The Journal also has a major role in continuing medical education and publishes review articles relevant to physician education.