Reprogramming Sex for Vector Control: Maleness-Associated Transgenes in Aedes albopictus.

IF 4.8 1区农林科学 Q1 BIOLOGY

Current opinion in insect science Pub Date : 2025-09-19 DOI:10.1016/j.cois.2025.101438

Doron Shalom Yishai Zaada, Philippos Aris Papathanos, Eric Marois

引用次数: 0

Abstract

Among other challenges, the world currently faces the expansion of pest insects such as the tiger mosquito Aedes albopictus, a growing threat to public health due to the pathogens it can transmit. Current control approaches based on insecticides or elimination of mosquito larval breeding sites are insufficient to suppress this highly invasive species. The discovery of Nix, a gene necessary and sufficient to determine the male sex in this mosquito, opens new prospects for genetic control strategies, in particular those based on transgenes that convert females into males, or that reduce female fitness. Such forms of genetic control could be effective on larger spatial and time scales compared to classical control approaches. This overview of current and emerging genetic control strategies targeting Aedes mosquitoes emphasizes the unique characteristics of Ae. albopictus, that make it particularly amenable to masculinization-based genetic control.

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媒介控制的性别重编程：白纹伊蚊雄性相关基因。

除其他挑战外，世界目前面临着诸如虎蚊白纹伊蚊等害虫的扩大，由于它可以传播病原体，对公共卫生构成越来越大的威胁。目前基于杀虫剂或消灭蚊子幼虫孳生地的控制方法不足以抑制这种高度侵入性物种。Nix基因是决定这种蚊子性别的必要且充分的基因，它的发现为基因控制策略开辟了新的前景，特别是那些基于将雌性转化为雄性或降低雌性适应性的转基因的策略。与传统的控制方法相比，这种形式的遗传控制可以在更大的空间和时间尺度上有效。本文概述了当前和新兴的针对伊蚊的遗传控制策略，强调了伊蚊的独特特征。白纹伊蚊，这使得它特别容易受到基于男性化的基因控制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current opinion in insect science BIOLOGYECOLOGYENTOMOLOGY-ECOLOGY

CiteScore

10.40

自引率

1.90%

发文量

113

期刊介绍： Current Opinion in Insect Science is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up–to–date with the expanding volume of information published in the field of Insect Science. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following 11 areas are covered by Current Opinion in Insect Science. -Ecology -Insect genomics -Global Change Biology -Molecular Physiology (Including Immunity) -Pests and Resistance -Parasites, Parasitoids and Biological Control -Behavioural Ecology -Development and Regulation -Social Insects -Neuroscience -Vectors and Medical and Veterinary Entomology There is also a section that changes every year to reflect hot topics in the field. Section Editors, who are major authorities in their area, are appointed by the Editors of the journal. They divide their section into a number of topics, ensuring that the field is comprehensively covered and that all issues of current importance are emphasized. Section Editors commission articles from leading scientists on each topic that they have selected and the commissioned authors write short review articles in which they present recent developments in their subject, emphasizing the aspects that, in their opinion, are most important. In addition, they provide short annotations to the papers that they consider to be most interesting from all those published in their topic over the previous year.