{"title":"Pathogenesis of rheumatoid arthritis: one year in review 2025.","authors":"Giulia Noto, Francesca Salvetti, Adriana Demaj, Piera Altieri, Erica Chericoni, Elisa Ferrigno, Alessia Alunno, Ilaria Puxeddu","doi":"10.55563/clinexprheumatol/53rkan","DOIUrl":null,"url":null,"abstract":"<p><p>Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterised by joint destruction and extra-articular manifestations. A close interaction between both innate and adaptive immune systems leads to the development of the clinical features of the disease, characterised by inflammation and structural changes. Progress in the basic and clinical research in the field of RA has improved the current knowledge on the mechanisms underlying its pathogenesis. The data obtained from basic and clinical studies in RA has actively contributed to identifying new potential targets for novel therapeutic approaches to design personalised therapy of the disease.</p>","PeriodicalId":10274,"journal":{"name":"Clinical and experimental rheumatology","volume":"43 9","pages":"1533-1540"},"PeriodicalIF":3.4000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and experimental rheumatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.55563/clinexprheumatol/53rkan","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/18 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterised by joint destruction and extra-articular manifestations. A close interaction between both innate and adaptive immune systems leads to the development of the clinical features of the disease, characterised by inflammation and structural changes. Progress in the basic and clinical research in the field of RA has improved the current knowledge on the mechanisms underlying its pathogenesis. The data obtained from basic and clinical studies in RA has actively contributed to identifying new potential targets for novel therapeutic approaches to design personalised therapy of the disease.
期刊介绍:
Clinical and Experimental Rheumatology is a bi-monthly international peer-reviewed journal which has been covering all clinical, experimental and translational aspects of musculoskeletal, arthritic and connective tissue diseases since 1983.