Epetraborole pharmacokinetics/pharmacodynamics in the hollow fiber system model of Mycobacterium tuberculosis.

IF 4.5 2区医学 Q2 MICROBIOLOGY

Antimicrobial Agents and Chemotherapy Pub Date : 2025-09-22 DOI:10.1128/aac.00481-25

Sanjay Singh, Megan Devine, Tawanda Gumbo, Shashikant Srivastava

引用次数: 0

Abstract

In the hollow fiber system model of tuberculosis (TB), the ratio of area under the concentration-time curve to MIC (AUC_0-24/MIC) of 327.1 was identified as the epetraborole optimal exposure target for Mycobacterium tuberculosis kill. Monte Carlo simulation experiments showed that even the intravenous dose of 1,500 mg/twice daily would fail in the majority of patients, and the dose needed for good efficacy for TB may likely not be safe for patients.

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在结核分枝杆菌中空纤维系统模型中埃伯罗勒的药代动力学/药效学。

在结核（TB）中空纤维系统模型中，确定浓度-时间曲线下面积与MIC之比（AUC0-24/MIC）为327.1为埃伯罗勒对结核分枝杆菌杀伤的最佳暴露靶点。Monte Carlo模拟实验表明，即使静脉注射剂量为1500mg /每日两次，对大多数患者来说也会失败，而且对结核病产生良好疗效所需的剂量可能对患者不安全。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Antimicrobial Agents and Chemotherapy 医学-微生物学

CiteScore

10.00

自引率

8.20%

发文量

762

审稿时长

3 months

期刊介绍： Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.