Atrial Fibrillation Elevates Stroke, Bleeding, and Cost in U.S. Aortic Aneurysm Admissions: Insights from the National Inpatient Sample.

IF 1.6 4区 医学 Q3 PERIPHERAL VASCULAR DISEASE
Ali Salman, Areeka Irfan, Mariam Shahabi, Muteia Shakoor, Mohammad Ismail Asim, Areeba Gul, Ali Roomi Khuwaja, Muhammad Usman Baig, Shahzeb Arif Khatri, Fakiha Hussain, Muhammad Talha Maniya, Muhammad Shikaib Shabbir, Ahmed Ali Aziz
{"title":"Atrial Fibrillation Elevates Stroke, Bleeding, and Cost in U.S. Aortic Aneurysm Admissions: Insights from the National Inpatient Sample.","authors":"Ali Salman, Areeka Irfan, Mariam Shahabi, Muteia Shakoor, Mohammad Ismail Asim, Areeba Gul, Ali Roomi Khuwaja, Muhammad Usman Baig, Shahzeb Arif Khatri, Fakiha Hussain, Muhammad Talha Maniya, Muhammad Shikaib Shabbir, Ahmed Ali Aziz","doi":"10.1016/j.avsg.2025.09.015","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Aortic aneurysm (AA) and atrial fibrillation (AF) frequently coexist, with emerging evidence suggesting that such patients exhibit an elevated cardiovascular risk profile. However, the impact of preexisting AF on in-hospital outcomes among patients hospitalized for AA remains poorly characterized.</p><p><strong>Methods: </strong>We analyzed data from the National Inpatient Sample (2018-2020) to identify adult hospitalizations with a primary diagnosis of AA. Patients were stratified by the presence or absence of AF. Multivariable logistic and linear regression were used to assess the association of AF with in-hospital mortality, complications, length of stay (LOS), and inflation-adjusted total hospital charges.</p><p><strong>Results: </strong>Among 147,420 weighted AA hospitalizations (mean age: 70 ±12 years), 39,030 (19.5%) had concomitant AF. After multivariable adjustment, AF was not significantly associated with in-hospital mortality (OR: 1.07 [0.90, 1.27], p=0.46). However, patients with AF had a longer median LOS (5 vs. 2 days; p<0.001) and incurred higher total charges ($160,363 vs. $129,647; p<0.001). AF was independently associated with increased odds of ischemic stroke (OR: 1.85 [1.36, 2.51], p<0.001), transient ischemic attack (OR: 1.96 [1.01, 3.80], p=0.047), acute myocardial infarction (OR: 1.58 [1.23, 2.04], p<0.001), and major (OR: 1.21 [1.01, 1.45], p=0.035) and transfusion-requiring bleeding (OR: 1.90 [1.04, 3.47], p=0.035).</p><p><strong>Conclusion: </strong>Although AF was not associated with in-hospital mortality among patients admitted for AA, it was linked to a significantly higher risk of bleeding complications, prolonged hospitalization, and greater healthcare expenditures.</p>","PeriodicalId":8061,"journal":{"name":"Annals of vascular surgery","volume":" ","pages":""},"PeriodicalIF":1.6000,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of vascular surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.avsg.2025.09.015","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Aortic aneurysm (AA) and atrial fibrillation (AF) frequently coexist, with emerging evidence suggesting that such patients exhibit an elevated cardiovascular risk profile. However, the impact of preexisting AF on in-hospital outcomes among patients hospitalized for AA remains poorly characterized.

Methods: We analyzed data from the National Inpatient Sample (2018-2020) to identify adult hospitalizations with a primary diagnosis of AA. Patients were stratified by the presence or absence of AF. Multivariable logistic and linear regression were used to assess the association of AF with in-hospital mortality, complications, length of stay (LOS), and inflation-adjusted total hospital charges.

Results: Among 147,420 weighted AA hospitalizations (mean age: 70 ±12 years), 39,030 (19.5%) had concomitant AF. After multivariable adjustment, AF was not significantly associated with in-hospital mortality (OR: 1.07 [0.90, 1.27], p=0.46). However, patients with AF had a longer median LOS (5 vs. 2 days; p<0.001) and incurred higher total charges ($160,363 vs. $129,647; p<0.001). AF was independently associated with increased odds of ischemic stroke (OR: 1.85 [1.36, 2.51], p<0.001), transient ischemic attack (OR: 1.96 [1.01, 3.80], p=0.047), acute myocardial infarction (OR: 1.58 [1.23, 2.04], p<0.001), and major (OR: 1.21 [1.01, 1.45], p=0.035) and transfusion-requiring bleeding (OR: 1.90 [1.04, 3.47], p=0.035).

Conclusion: Although AF was not associated with in-hospital mortality among patients admitted for AA, it was linked to a significantly higher risk of bleeding complications, prolonged hospitalization, and greater healthcare expenditures.

房颤增加卒中、出血和美国主动脉瘤住院费用:来自全国住院患者样本的见解。
背景:主动脉瘤(AA)和心房颤动(AF)经常共存,新出现的证据表明这类患者心血管风险升高。然而,在因房颤住院的患者中,既往房颤对住院结果的影响尚不清楚。方法:我们分析了全国住院患者样本(2018-2020)的数据,以确定初步诊断为AA的成人住院病例。根据是否存在房颤对患者进行分层。采用多变量逻辑回归和线性回归来评估房颤与住院死亡率、并发症、住院时间(LOS)和经通货膨胀调整的医院总收费之间的关系。结果:147,420例加权AA住院患者(平均年龄:70±12岁)中,39,030例(19.5%)合并房颤。多变量校正后,房颤与住院死亡率无显著相关性(OR: 1.07 [0.90, 1.27], p=0.46)。结论:虽然房颤与因AA入院的患者的住院死亡率无关,但它与出血并发症的风险显著增加、住院时间延长和医疗费用增加有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
3.00
自引率
13.30%
发文量
603
审稿时长
50 days
期刊介绍: Annals of Vascular Surgery, published eight times a year, invites original manuscripts reporting clinical and experimental work in vascular surgery for peer review. Articles may be submitted for the following sections of the journal: Clinical Research (reports of clinical series, new drug or medical device trials) Basic Science Research (new investigations, experimental work) Case Reports (reports on a limited series of patients) General Reviews (scholarly review of the existing literature on a relevant topic) Developments in Endovascular and Endoscopic Surgery Selected Techniques (technical maneuvers) Historical Notes (interesting vignettes from the early days of vascular surgery) Editorials/Correspondence
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信