The multidimensional role of laminin γ2 (LAMC2) on cancer progression

IF 2.1 4区医学 Q4 GENETICS & HEREDITY

Cancer Genetics Pub Date : 2025-09-16 DOI:10.1016/j.cancergen.2025.09.007

Xiaojuan Zhang , Juan Xie , Tao Fu , Zhen Gao , Hengrui Liu , Zhenshan Yang

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引用次数: 0

Abstract

Laminin, a critical component of the basement membrane, plays an indispensable role in numerous biological processes. Among its subunits, laminin γ2 (LAMC2) emerges as a key player in the progression of cancer. This review delves into the current understanding of LAMC2′s role, highlighting its significant contribution to cancer development through promoting cell proliferation, invasion, and vasculogenic mimicry, as well as inhibiting apoptosis. Notably, LAMC2 expression is markedly increased in cancerous tissues compared to normal counterparts, with higher levels of LAMC2 correlating with poorer survival rates. This correlation underscores LAMC2′s potential as a diagnostic and prognostic marker across various cancers. Furthermore, the increasing importance of LAMC2 as a viable target for cancer therapy is explored. This review aims to provide a thorough overview of LAMC2′s involvement in cancer progression, prognostic implications, potential therapeutic target, and involved signaling pathway, and to outline future research directions in this promising field.

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层粘连蛋白γ - 2 （LAMC2）在癌症进展中的多维作用

层粘连蛋白是基底膜的重要组成部分，在许多生物过程中起着不可或缺的作用。在其亚基中，层粘连蛋白γ - 2 （LAMC2）在癌症的进展中起着关键作用。这篇综述深入了目前对LAMC2作用的理解，强调了它通过促进细胞增殖、侵袭和血管生成模拟以及抑制细胞凋亡对癌症发展的重要贡献。值得注意的是，与正常组织相比，LAMC2在癌组织中的表达明显增加，LAMC2水平越高，生存率越低。这种相关性强调了LAMC2作为各种癌症的诊断和预后标志物的潜力。此外，LAMC2作为一种可行的癌症治疗靶点的重要性日益增加。本文旨在全面综述LAMC2在癌症进展中的作用、预后意义、潜在的治疗靶点和涉及的信号通路，并概述这一前景广阔的领域的未来研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Genetics ONCOLOGY-GENETICS & HEREDITY

CiteScore

3.20

自引率

5.30%

发文量

167

审稿时长

27 days

期刊介绍： The aim of Cancer Genetics is to publish high quality scientific papers on the cellular, genetic and molecular aspects of cancer, including cancer predisposition and clinical diagnostic applications. Specific areas of interest include descriptions of new chromosomal, molecular or epigenetic alterations in benign and malignant diseases; novel laboratory approaches for identification and characterization of chromosomal rearrangements or genomic alterations in cancer cells; correlation of genetic changes with pathology and clinical presentation; and the molecular genetics of cancer predisposition. To reach a basic science and clinical multidisciplinary audience, we welcome original full-length articles, reviews, meeting summaries, brief reports, and letters to the editor.