Acquired cystic disease-associated renal cell carcinoma: A case report

IF 0.7 Q4 SURGERY

International Journal of Surgery Case Reports Pub Date : 2025-09-22 DOI:10.1016/j.ijscr.2025.111973

Imen Helal , Farah Loued , Ehsen Ben Brahim , Mohamed Amine Oueslati , Raja Jouini , Aschraf Chadli-Debbiche

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Abstract

Introduction

Acquired cystic kidney disease (ACKD) affects almost half of patients with chronic hemodialysis. ACKD is recognized as a predisposing condition for renal carcinoma, particularly in patients undergoing long-term dialysis. Acquired cystic disease-associated renal cell carcinoma (ACD-RCC) is a subtype of renal cell carcinoma (RCC) occurring solely in patients with ACKD. ACD-RCC was first introduced as a distinct entity in the 2016 World Health Organization (WHO) classification of renal tumors and retained in the 2022 update. However, it remains underdiagnosed due to histologic overlap with other subtypes. We aimed to study the clinicopathological features of the entity.

Case presentation

We reported the case of a 44-year-old patient who presented a hemorrhagic shock of suspected renal origin. A scan showed no renal tumor. The patient experienced a second episode of hemorrhagic shock. A hemostatic nephrectomy was necessary. Microscopic examination confirmed the diagnosis of ACD-RCC. The patient died three days post-operatively.

Clinical discussion

ACD-RCC is a common but under recognized entity with specific clinical, histopathological, and evolutionary features.

Conclusion

Enhanced recognition of ACD-RCC and its features by pathologists is mandatory to ensure accurate histopathological diagnosis and appropriate clinical management.

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获得性囊性病相关肾细胞癌1例报告

获得性囊性肾病（ACKD）影响近一半的慢性血液透析患者。ACKD被认为是肾癌的易感因素，特别是长期透析的患者。获得性囊性疾病相关肾细胞癌（ACD-RCC）是一种仅发生于ACKD患者的肾细胞癌（RCC）亚型。ACD-RCC在2016年世界卫生组织（WHO）肾脏肿瘤分类中首次作为一个独立的实体引入，并在2022年更新中保留。然而，由于与其他亚型的组织学重叠，它仍未得到充分诊断。我们的目的是研究该实体的临床病理特征。我们报告了一例44岁的病人，他表现出疑似肾源性失血性休克。扫描显示没有肾肿瘤。病人经历了第二次失血性休克。止血肾切除术是必要的。镜检证实为ACD-RCC。患者术后3天死亡。acd - rcc是一种常见的但尚未得到认可的实体，具有特定的临床、组织病理学和进化特征。结论病理学家必须提高对ACD-RCC及其特征的认识，以确保准确的组织病理学诊断和适当的临床治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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