Burden and its associated factors of neonatal necrotizing enter colitis among neonates admitted in neonatal intensive care unit in Ethiopia. A systematic review and meta-analysis

Q2 Nursing

International Journal of Africa Nursing Sciences Pub Date : 2025-01-01 DOI:10.1016/j.ijans.2025.100899

Demewoz Kefale , Worku Necho Asferie , Tigabu Munye Aytenew , Gedefaw Abeje Masresha , Mahilet Wondim , Misganaw Abie Tassew , Kidist Hunegn Setargew , Yeshiambaw Eshetie , Solomon Demis Kebede

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引用次数: 0

Abstract

Neonatal Necrotizing enterocolitis is the most critical and recurrent gastrointestinal disorder in neonatal intensive care units. Although the overall mortality extends to 50 % related to necrotizing enterocolitis, it can approach 100 % with perforation, peritonitis and sepsis complications. It is the first step to planning management approaches that can contribute to decreasing long term morbidity and mortality. The aim of this systematic review and meta-analysis was to assess the prevalence and its determinant factors of necrotizing enterocolitis among admitted neonates in Ethiopia. The procedure of this systematic review and meta-analysis was registered at the Prospero with a registration number of CRD42023409175. Universal online databases such as PubMed, Cochrane, Google, Google Scholar, SCOPUS, and Web of science and Global health were used to search for articles. Data extraction was commenced with Microsoft Excel and STATA17 was used to conduct the Meta-Analysis. Random effect model analysis was considered when there was evidence of heterogeneity among the studies. The overall pooled prevalence of neonatal necrotizing enterocolitis was 14.4 % (95 % CI; 7.04, 21.85, I² = 95.80 %, p = 0.000). The pooled odds ratio of Birth weight (AOR = 3.75 (95 % CI; 1.72, 5.79), Apgar score (AOR = 2.37 (95 % CI; 1.83, 2.91), maternal infection (AOR = 5.24 (95 % CI; 4.04, 6.45) and prolonged labor (AOR = 2.70 (95 % CI; 1.65, 3.74) had significant statistical association with neonatal necrotizing enterocolitis. This finding concluded that high prevalence and multiple determinant factors of neonatal necrotizing enterocolitis in Ethiopia. This finding recommend that neonatal care programs prioritize targeting maternal infection prevention, improved labor management, and enhanced care for low birth weight neonates and those with low Apgar scores to decrease the unacceptably high burden of neonatal necrotizing enterocolitis and its devastating consequences.

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埃塞俄比亚新生儿重症监护病房新生儿坏死性进入性结肠炎的负担及其相关因素系统回顾和荟萃分析

新生儿坏死性小肠结肠炎是新生儿重症监护病房最严重和复发性的胃肠道疾病。虽然坏死性小肠结肠炎的总死亡率可达50%，但穿孔、腹膜炎和脓毒症并发症的死亡率可接近100%。这是规划有助于降低长期发病率和死亡率的管理办法的第一步。本系统综述和荟萃分析的目的是评估埃塞俄比亚住院新生儿坏死性小肠结肠炎的患病率及其决定因素。本系统评价和荟萃分析的程序在普洛斯彼罗注册，注册号为CRD42023409175。使用PubMed、Cochrane、谷歌、谷歌Scholar、SCOPUS和Web of science and Global health等通用在线数据库搜索文章。使用Microsoft Excel开始数据提取，使用STATA17进行meta分析。当有证据表明研究之间存在异质性时，考虑随机效应模型分析。新生儿坏死性小肠结肠炎的总总患病率为14.4% （95% CI; 7.04, 21.85, I2 = 95.80%, p = 0.000）。出生体重(AOR = 3.75 （95% CI; 1.72, 5.79）、Apgar评分(AOR = 2.37 （95% CI; 1.83, 2.91）、母体感染(AOR = 5.24 （95% CI; 4.04, 6.45）、产程延长(AOR = 2.70 （95% CI; 1.65, 3.74）与新生儿坏死性小肠结肠炎的合并优势比具有统计学意义。这一发现表明埃塞俄比亚新生儿坏死性小肠结肠炎的高患病率和多重决定因素。这一发现建议新生儿护理计划优先针对孕产妇感染预防，改善分娩管理，加强对低出生体重新生儿和低Apgar评分的新生儿的护理，以减少新生儿坏死性小肠结肠炎的不可接受的高负担及其破坏性后果。

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来源期刊

International Journal of Africa Nursing Sciences Nursing-Nursing (all)

CiteScore

2.40

自引率

0.00%

发文量

114

审稿时长

21 weeks

期刊介绍： International Journal of Africa Nursing Sciences (IJANS) is an international scientific journal published by Elsevier. The broad-based journal was founded on two key tenets, i.e. to publish the most exciting research with respect to the subjects of Nursing and Midwifery in Africa, and secondly, to advance the international understanding and development of nursing and midwifery in Africa, both as a profession and as an academic discipline. The fully refereed journal provides a forum for all aspects of nursing and midwifery sciences, especially new trends and advances. The journal call for original research papers, systematic and scholarly review articles, and critical papers which will stimulate debate on research, policy, theory or philosophy of nursing as related to nursing and midwifery in Africa, technical reports, and short communications, and which will meet the journal''s high academic and ethical standards. Manuscripts of nursing practice, education, management, and research are encouraged. The journal values critical scholarly debate on issues that have strategic significance for educators, practitioners, leaders and policy-makers of nursing and midwifery in Africa. The journal publishes the highest quality scholarly contributions reflecting the diversity of nursing, and is also inviting international scholars who are engaged with nursing and midwifery in Africa to contribute to the journal. We will only publish work that demonstrates the use of rigorous methodology as well as by publishing papers that highlight the theoretical underpinnings of nursing and midwifery as it relates to the Africa context.