A systematic review of residential proximity to upstream oil and gas development and childhood, adolescent and young adult cancer risk.

IF 3.7 4区 医学 Q1 PEDIATRICS
Eric C Stewart, Nicholaus P Johnson, Cassandra J Clark, Catherine Metayer, Nicole C Deziel
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引用次数: 0

Abstract

Objective: Upstream oil and gas development (OGD) can release carcinogenic and radioactive agents into air and water. This review summarizes evidence on the relationship between residential proximity to upstream OGD and cancer risk among children, adolescents, and young adults (CAYA).

Methods: We systematically searched PubMed and Embase through April 25, 2025, for original, peer-reviewed epidemiologic investigations of residential proximity to upstream OGD and cancer in CAYA (≤25 years). We excluded studies of downstream activity, those lacking CAYA-specific results, and non-English publications. Two reviewers independently screened records, extracted data, and assessed risk of bias with a World Health Organization tool.

Results: From 3274 screened articles, 10 met inclusion criteria. Four case-control studies, all United States-based (Pennsylvania n = 3, Colorado n = 1), used individual-level proximity metrics during defined temporal windows and controlled for confounders. Six ecological studies (Ecuador n = 4, Croatia n = 1, Pennsylvania n = 1) used area-based density or binary exposure metrics with limited confounder adjustment. All studies assessed hematopoietic malignancies. All case-control studies observed positive associations between OGD proximity and cancer with three reporting elevated leukemia risk. Two studies from different states reported highly similar leukemia risk in the closest OGD buffer zones (Colorado: 3 km OR 2.07, 95 % CI 1.08-3.74; Pennsylvania: 2 km OR 1.98, 95 % CI 1.06-3.69). Ecologic study findings were mixed, including elevated risks for hematologic and central nervous system cancers. Limitations include few studies, imprecise exposure metrics, and potential residual confounding.

Discussion: Despite limited evidence, the majority of studies reported positive, statistically significant associations between OGD and childhood cancer, most consistently for leukemia, supporting efforts to reduce OGD proximity to children.

一项关于上游油气开发与儿童、青少年和年轻人癌症风险的系统综述。
目的:上游油气开发会向大气和水体中释放致癌物和放射性物质。这篇综述总结了居住靠近上游OGD与儿童、青少年和年轻人(CAYA)癌症风险之间关系的证据。方法:我们系统地检索了PubMed和Embase,截至2025年4月25日,检索了CAYA(≤25年)中居住邻近上游OGD和癌症的原始同行评审流行病学调查。我们排除了下游活性研究、缺乏caia特异性结果的研究和非英文出版物。两名审稿人独立筛选记录,提取数据,并使用世界卫生组织的工具评估偏倚风险。结果:在筛选的3274篇文章中,10篇符合纳入标准。四项病例对照研究均以美国为基地(宾夕法尼亚州n = 3,科罗拉多州n = 1),在规定的时间窗口内使用个人水平接近指标,并控制混杂因素。6项生态学研究(厄瓜多尔n = 4,克罗地亚n = 1,宾夕法尼亚州n = 1)使用基于区域的密度或二元暴露指标,并进行有限的混杂校正。所有的研究都评估了造血恶性肿瘤。所有病例对照研究均观察到OGD邻近与癌症呈正相关,其中3例报告白血病风险升高。来自不同州的两项研究报告了最近的OGD缓冲区的白血病风险高度相似(科罗拉多州:3公里OR 2.07, 95% CI 1.08-3.74;宾夕法尼亚州:2公里OR 1.98, 95% CI 1.06-3.69)。生态学研究结果好坏参半,包括血液学和中枢神经系统癌症的风险增加。局限性包括研究较少、暴露指标不精确和潜在的残留混淆。讨论:尽管证据有限,但大多数研究报告了OGD与儿童癌症之间积极的、统计学上显著的关联,其中最一致的是白血病,这支持了减少OGD与儿童接触的努力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
61
审稿时长
5 days
期刊介绍: Recognized for its probing, comprehensive, and evidence-based reviews, Current Problems in Pediatric and Adolescent Health Care devotes each issue to a timely and practical topic in pediatric medicine, presented by leading authorities in the field. The journal offers readers easily accessible information that enhances professional experience and is pertinent to daily pediatric practice. Each issue''s review article is accompanied by an additional special feature designed to highlight a particular aspect of the topic presented.
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