Accelerometer-measured physical activity, sedentary behavior, and incident neuropsychiatric diseases: a large prospective cohort study of 73411 participants.

IF 10.1 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Jia-Yi Wu, Yu-Zhu Li, Dan-Dan Zhang, Pei-Yang Gao, Yan Fu, Wei Zhang, Jian-Feng Feng, Ya-Ru Zhang, Wei Cheng, Jin-Tai Yu
{"title":"Accelerometer-measured physical activity, sedentary behavior, and incident neuropsychiatric diseases: a large prospective cohort study of 73411 participants.","authors":"Jia-Yi Wu, Yu-Zhu Li, Dan-Dan Zhang, Pei-Yang Gao, Yan Fu, Wei Zhang, Jian-Feng Feng, Ya-Ru Zhang, Wei Cheng, Jin-Tai Yu","doi":"10.1038/s41380-025-03268-7","DOIUrl":null,"url":null,"abstract":"<p><p>Physical activity and sedentary behavior are closely associated with neuropsychiatric diseases, while previous studies have mainly relied on self-reported data, which have been shown to be inconsistent with objectively measured metrics. Using data from 73,411 participants, objectively quantifying physical activity through energy expenditure and time allocation, we identified longitudinal associations between physical activity, sedentary behavior, and neuropsychiatric diseases using Cox proportional hazards models. Our findings indicated that moderate to vigorous physical activity energy expenditure showed the strongest protective effect on neuropsychiatric diseases (hazard ratios: 0.60-0.86, all FDR-Q < 0.001), while an increased proportion of sedentary time was identified as a risk factor for neuropsychiatric diseases (HRs: 1.05-1.54, FDR-Q < 0.05). Restricted cubic spline analyses demonstrated an L-shaped association linking physical activity and neuropsychiatric diseases and an inverted L-shaped relationship between sedentary behavior and dementia. Linear regression models further linked physical activity and sedentary behavior to cognitive function, physical function, and mental health. Key brain regions related to these behaviors included the lateral occipital cortex, cuneus, pallidum, and accumbens. Proteomics and metabolic analyses identified significant involvement of ITGAV protein and high-intensity lipoprotein. Structural equation modeling elucidated that inflammation and metabolism mediate the relationship between physical activity, sedentary behavior, and neuropsychiatric diseases. Overall, our study provides critical evidence of the link between physical activity, sedentary behavior, and neuropsychiatric diseases, shedding light on potential neurobiological mechanisms underlying these associations.</p>","PeriodicalId":19008,"journal":{"name":"Molecular Psychiatry","volume":" ","pages":""},"PeriodicalIF":10.1000,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41380-025-03268-7","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Physical activity and sedentary behavior are closely associated with neuropsychiatric diseases, while previous studies have mainly relied on self-reported data, which have been shown to be inconsistent with objectively measured metrics. Using data from 73,411 participants, objectively quantifying physical activity through energy expenditure and time allocation, we identified longitudinal associations between physical activity, sedentary behavior, and neuropsychiatric diseases using Cox proportional hazards models. Our findings indicated that moderate to vigorous physical activity energy expenditure showed the strongest protective effect on neuropsychiatric diseases (hazard ratios: 0.60-0.86, all FDR-Q < 0.001), while an increased proportion of sedentary time was identified as a risk factor for neuropsychiatric diseases (HRs: 1.05-1.54, FDR-Q < 0.05). Restricted cubic spline analyses demonstrated an L-shaped association linking physical activity and neuropsychiatric diseases and an inverted L-shaped relationship between sedentary behavior and dementia. Linear regression models further linked physical activity and sedentary behavior to cognitive function, physical function, and mental health. Key brain regions related to these behaviors included the lateral occipital cortex, cuneus, pallidum, and accumbens. Proteomics and metabolic analyses identified significant involvement of ITGAV protein and high-intensity lipoprotein. Structural equation modeling elucidated that inflammation and metabolism mediate the relationship between physical activity, sedentary behavior, and neuropsychiatric diseases. Overall, our study provides critical evidence of the link between physical activity, sedentary behavior, and neuropsychiatric diseases, shedding light on potential neurobiological mechanisms underlying these associations.

加速度计测量的身体活动、久坐行为和神经精神疾病:一项包含73411名参与者的大型前瞻性队列研究。
体力活动和久坐行为与神经精神疾病密切相关,而之前的研究主要依赖于自我报告的数据,这些数据已被证明与客观测量指标不一致。使用来自73,411名参与者的数据,通过能量消耗和时间分配客观量化身体活动,我们使用Cox比例风险模型确定了身体活动、久坐行为和神经精神疾病之间的纵向关联。我们的研究结果表明,中度至剧烈的体力活动能量消耗对神经精神疾病的保护作用最强(风险比:0.60-0.86,所有FDR-Q)
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Molecular Psychiatry
Molecular Psychiatry 医学-精神病学
CiteScore
20.50
自引率
4.50%
发文量
459
审稿时长
4-8 weeks
期刊介绍: Molecular Psychiatry focuses on publishing research that aims to uncover the biological mechanisms behind psychiatric disorders and their treatment. The journal emphasizes studies that bridge pre-clinical and clinical research, covering cellular, molecular, integrative, clinical, imaging, and psychopharmacology levels.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信