Blood Flow Simulation and Uncertainty Quantification in Extensive Microvascular Networks: Application to Brain Cortical Networks

IF 2 4区 医学 Q3 HEMATOLOGY
Peter Mondrup Rasmussen
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引用次数: 0

Abstract

Objective

Microvascular blood flow simulations enhance understanding of microcirculatory phenomena at the micrometer scale by capturing heterogeneity in blood flow. However, imaged areas often only partially represent tissue regions, leading to numerous vessels crossing boundaries and strongly influencing simulated blood flows through imposed boundary conditions.

Methods

Two key methodological aspects of blood flow simulations are addressed: selecting appropriate boundary conditions and quantifying the inevitable impact of boundary condition uncertainties on model simulations. An adaptive method for pressure boundary conditions is proposed and rigorously evaluated in extensive brain cortical microvascular networks. The adaptive method is integrated into a Bayesian calibration framework, inferring distributions over thousands of unknown pressure boundary conditions and providing uncertainty estimates for model simulations.

Results

The adaptive method produces simulations consistent with reference data, yielding depth-dependent pressure drop profiles and layer-wise capillary blood flow profiles consistent with previous analysis. These hemodynamic phenomena generalize to biphasic blood flow simulation models incorporating in vivo viscosity formulations. Uncertainty quantification reveals a novel spatially heterogeneous and depth-dependent pattern in blood flow uncertainty.

Conclusions

The adaptive method for pressure boundary conditions will be useful in future applications of both forward and inverse blood flow simulations. Uncertainty quantification complements hemodynamic predictions with associated uncertainties.

Abstract Image

广泛微血管网络中的血流模拟和不确定性量化:在脑皮质网络中的应用
目的微血管血流模拟通过捕捉血流的异质性,增强对微米尺度微循环现象的认识。然而,成像区域通常仅部分代表组织区域,导致大量血管跨越边界,并通过强加的边界条件强烈影响模拟血液流动。方法研究血流模拟的两个关键方法学方面:选择合适的边界条件和量化边界条件不确定性对模型模拟的不可避免的影响。提出了一种压力边界条件的自适应方法,并在广泛的脑皮质微血管网络中进行了严格的评估。自适应方法集成到贝叶斯校准框架中,推断数千个未知压力边界条件的分布,并为模型模拟提供不确定性估计。结果自适应方法得到的模拟结果与参考数据一致,得到了与深度相关的压降曲线和与先前分析一致的分层毛细血管血流曲线。这些血流动力学现象推广到结合体内黏度配方的双相血流模拟模型。不确定度量化揭示了血流不确定度的一种新的空间异质性和深度依赖性模式。结论压力边界条件的自适应方法在血流正反向模拟中具有一定的应用价值。不确定度量化补充了相关不确定度的血流动力学预测。
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来源期刊
Microcirculation
Microcirculation 医学-外周血管病
CiteScore
5.00
自引率
4.20%
发文量
43
审稿时长
6-12 weeks
期刊介绍: The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.
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