Amplitude of brain low-frequency fluctuation and functional connectivity changes based on fMRI study in first-episode major depressive disorder

IF 1.6 4区医学 Q3 CLINICAL NEUROLOGY

Clinical Neurology and Neurosurgery Pub Date : 2025-09-15 DOI:10.1016/j.clineuro.2025.109157

Yanting Zheng , Huai Tu , Danian Li , Jing Wang , Baohua Cheng , Jie Zhou , Shijun Qiu , Yujie Liu

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引用次数: 0

Abstract

Objective

Recent functional connectivity (FC) studies have proved the potential value of resting-state functional magnetic resonance imaging (rs-fMRI) in the study of major depressive disorder (MDD). This study investigates alterations of amplitude of low-frequency fluctuations (ALFF) in first-episode major depressive disorder (FED) using rs-fMRI, and then explore the abnormalities of FC.

Methods

A total of 66 FED patients and 66 healthy controls were recruited for this study. The amplitude of low frequency fluctuations (ALFF) method was employed to assess changes in brain activity across the entire brain in both groups. Subsequently, the identified brain regions were used as seeds to examine whole-brain functional connectivity (FC) changes. Additionally, we conducted partial correlation analyses to investigate the relationship between functional connectivity values in FED patients and clinical variables, such as the 17-item Hamilton Depression Rating Scale (HAMD-17) scores and illness duration.

Results

FED patients exhibited increased ALFF values in the right fusiform and the right parahippocampal gyrus compared to controls (P < 0.05, GRF correction). Enhanced FC was observed between the right parahippocampal gyrus and the right precentral gyrus, with reduced connectivity to the brainstem (P < 0.05, GRF correction). The FC values of the right parahippocampal gyrus and right precentral gyrus positively correlated with the HAMD-17 scores (r = 0.314, P = 0.012).

Conclusion

Abnormal ALFF and FC in several brain regions of FED patients suggest these areas could serve as biological markers for identifying FED.

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基于fMRI的首发重度抑郁症脑低频波动幅度及功能连通性变化研究

目的最近的功能连接（FC）研究证实了静息状态功能磁共振成像（rs-fMRI）在重度抑郁症（MDD）研究中的潜在价值。本研究利用磁共振成像（rs-fMRI）研究首发重性抑郁障碍（FED）患者低频波动幅度（ALFF）的变化，并探讨其FC的异常。方法共招募66例FED患者和66例健康对照者。采用低频波动幅度（ALFF）方法评估两组患者整个大脑活动的变化。随后，确定的大脑区域被用作检查全脑功能连接（FC）变化的种子。此外，我们还进行了偏相关分析，以研究FED患者的功能连接值与临床变量（如17项汉密尔顿抑郁评定量表（HAMD-17）得分和病程）之间的关系。结果与对照组相比，fed患者右侧梭状回和右侧海马旁回ALFF值升高（P <； 0.05，GRF校正）。右侧海马旁回和右侧中央前回之间的FC增强，与脑干的连通性降低（P <； 0.05，GRF校正）。右侧海马旁回和右侧中央前回的FC值与HAMD-17评分呈正相关（r = 0.314,P = 0.012）。结论联食症患者部分脑区ALFF和FC异常，提示这些区域可作为联食症的生物学标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurology and Neurosurgery 医学-临床神经学

CiteScore

3.70

自引率

5.30%

发文量

358

审稿时长

46 days

期刊介绍： Clinical Neurology and Neurosurgery is devoted to publishing papers and reports on the clinical aspects of neurology and neurosurgery. It is an international forum for papers of high scientific standard that are of interest to Neurologists and Neurosurgeons world-wide.