Volumetric courses of the intraosseous and meningeal components of osteomeningiomas after cyproterone acetate treatment withdrawal.

IF 3.6 2区医学 Q1 CLINICAL NEUROLOGY

Journal of neurosurgery Pub Date : 2025-09-19 DOI:10.3171/2025.4.JNS25252

Paul E Constanthin, Virginie Montalibet, Mégane Le Quang, Morgan Ollivier, Olivier Saut, Annabelle Collin, Julien Engelhardt

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引用次数: 0

Abstract

Objective: Progestin exposure, such as with cyproterone acetate (CPA), could increase the risk of developing osteomeningiomas (OMs). This study investigated the volumetric dynamics of the meningeal and intraosseous components of these tumors and their correlation following CPA discontinuation.

Methods: This retrospective study included 17 patients with 21 OMs diagnosed during ongoing CPA treatment. Volumes of the meningeal and intraosseous components of the OMs were measured at multiple time points. Volume dynamics over time were modeled using linear, exponential, power, and Gompertz tumor growth models. Hormone receptor expression in both components was evaluated via immunohistochemical analysis in the 4 tumors on which surgery was performed.

Results: The Gompertz tumor growth model was the most accurate in fitting the data. After CPA cessation, the meningeal component showed volume reduction in 95% of tumors (a substantial decrease in 40% and a modest decrease in 55% of tumors). The intraosseous component exhibited sustained growth in all cases, characterized by three distinct dynamics: slowing growth (40%), linear growth (45%), and pseudo-exponential growth (15%). A significant correlation was observed between the volumetric courses in the two components (rho = 0.49, p = 0.03). Hormone receptor analysis revealed no differences in expression between the two components.

Conclusions: While the meningeal and intraosseous components of OMs respond differently to CPA withdrawal, their growth dynamics remain correlated.

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停止醋酸环丙孕酮治疗后骨内和脑膜部分骨脑膜瘤的体积变化。

目的：黄体酮暴露，如与醋酸环丙孕酮（CPA），可增加发生骨omeniniomas （OMs）的风险。本研究调查了这些肿瘤的脑膜和骨内成分的体积动力学及其在停药后的相关性。方法：本回顾性研究包括17例正在进行CPA治疗期间诊断的21例OMs。在多个时间点测量OMs的脑膜和骨内成分的体积。使用线性、指数、功率和Gompertz肿瘤生长模型对体积随时间的动态进行建模。通过免疫组化分析，对4例行手术的肿瘤进行两种成分的激素受体表达评估。结果：Gompertz肿瘤生长模型拟合数据最准确。停止CPA后，脑膜成分显示95%的肿瘤体积减少（40%的肿瘤体积大幅减少，55%的肿瘤体积适度减少）。所有病例的骨内构件均呈现持续生长，表现为三种不同的动态：缓慢生长（40%）、线性生长（45%）和伪指数生长（15%）。在两个成分的体积过程中观察到显著相关（rho = 0.49, p = 0.03）。激素受体分析显示，两种成分之间的表达没有差异。结论：虽然脑膜和骨内成分对CPA戒断的反应不同，但它们的生长动态仍然相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of neurosurgery 医学-临床神经学

CiteScore

7.20

自引率

7.30%

发文量

1003

审稿时长

1 months

期刊介绍： The Journal of Neurosurgery, Journal of Neurosurgery: Spine, Journal of Neurosurgery: Pediatrics, and Neurosurgical Focus are devoted to the publication of original works relating primarily to neurosurgery, including studies in clinical neurophysiology, organic neurology, ophthalmology, radiology, pathology, and molecular biology. The Editors and Editorial Boards encourage submission of clinical and laboratory studies. Other manuscripts accepted for review include technical notes on instruments or equipment that are innovative or useful to clinicians and researchers in the field of neuroscience; papers describing unusual cases; manuscripts on historical persons or events related to neurosurgery; and in Neurosurgical Focus, occasional reviews. Letters to the Editor commenting on articles recently published in the Journal of Neurosurgery, Journal of Neurosurgery: Spine, and Journal of Neurosurgery: Pediatrics are welcome.