Sex-specific prolactin disturbance and divergent gonadal hormone correlates in first-episode schizophrenia.

IF 3.7 2区医学 Q1 CLINICAL NEUROLOGY

International Journal of Neuropsychopharmacology Pub Date : 2025-09-13 DOI:10.1093/ijnp/pyaf068

Anle Pan, Jindong Wang, Jing Liang, Meihong Xiu, Qiang Hu, Shuangli Zhang

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引用次数: 0

Abstract

Background: Hyperprolactinemia and altered prolactin (PRL) levels are well-documented in schizophrenia. However, very few studies have investigated sex-specific differences in the prevalence of PRL disturbances in first-episode patients with schizophrenia. This cross-sectional study investigated sex-specific PRL dysregulation and its interplay with gonadal hormones in first-episode schizophrenia patients.

Methods: One hundred eighty-nine first-episode patients (96 males, 93 females) with minimally treated (≤2 weeks) were recruited. PRL levels and gonadal hormones were measured in all participants.

Results: We found a significantly higher prevalence of abnormal PRL levels in males compared to females (32.3% vs. 8.6%, χ2 = 16.2, p<.001). Comparative analysis of gonadal hormones between elevated PRL (n = 39) and normal PRL (n = 150) groups demonstrated elevated follicle-stimulating hormone (Z = 2.7, p=.007) and testosterone (Z = 3.7, p<.001) in the hyperprolactinemic group. In the elevated PRL group, PRL positively correlated with progesterone and testosterone, whereas in the normal PRL group, PRL showed positive associations with estradiol and luteinizing hormone, but negative correlations with progesterone.

Conclusions: Our findings underscore the complex and sex-specific nature of PRL dysregulation and its association with gonadal hormones in first-episode schizophrenia patients.

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首发精神分裂症患者性别特异性催乳素障碍与性激素分化相关。

背景：高催乳素血症和改变催乳素（PRL）水平在精神分裂症中有充分的证据。然而，很少有研究调查了首发精神分裂症患者PRL障碍患病率的性别差异。本横断面研究探讨首发精神分裂症患者性别特异性PRL失调及其与性腺激素的相互作用。方法：采用微创治疗（≤2周）首发患者189例（男96例，女93例）。测量所有参与者的PRL水平和性腺激素。结果：我们发现男性PRL水平异常的患病率明显高于女性（32.3%比8.6%,χ2 = 16.2）。结论：我们的研究结果强调了首发精神分裂症患者PRL失调的复杂性和性别特异性及其与性腺激素的相关性。

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来源期刊

International Journal of Neuropsychopharmacology 医学-精神病学

CiteScore

8.40

自引率

2.10%

发文量

230

审稿时长

4-8 weeks

期刊介绍： The central focus of the journal is on research that advances understanding of existing and new neuropsychopharmacological agents including their mode of action and clinical application or provides insights into the biological basis of psychiatric disorders and thereby advances their pharmacological treatment. Such research may derive from the full spectrum of biological and psychological fields of inquiry encompassing classical and novel techniques in neuropsychopharmacology as well as strategies such as neuroimaging, genetics, psychoneuroendocrinology and neuropsychology.