A bibliometric analysis on KRAS, a targeted marker for blockbuster clinical drugs

IF 2.4 Q3 Medicine

Cancer treatment and research communications Pub Date : 2025-01-01 DOI:10.1016/j.ctarc.2025.101001

Zongzhen Guo , Shiqing Zhao , Yanfei Sun , Yanyan Shi

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引用次数: 0

Abstract

This study aims to provide an overview of research hotspots and trends in KRAS, a key star gene which has been paid special attention to in the field of cancer. Publications on KRAS were searched in the Web of Science Core Collection database. VOSviewer 1.6.16 and R package “bibliometrix” were used for bibliometric analyses. A total of 23,758 publications were identified, including 19,325 original articles and 2913 reviews. A sharp increase of the publications number was found since the year 2016 by time trend analysis. The top 3 countries/regions with the highest number of publications were the United States, China and Europe. Most active organizations were from Europe and the USA. Keywords cooccurrence analysis showed four clusters of KRAS, including the role and molecular mechanism of KRAS in the process of cancer development, especially pancreatic cancer, studies on the characteristics and clinical value of KRAS in colorectal cancer, the role characteristics of KRAS in the occurrence of lung cancer and its clinical applications and research progress of clinical trials targeted KRAS. This study systematically elucidates emerging insights into the critical gene KRAS, providing a contemporary perspective on KRAS-driven oncogenesis.

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临床重磅药物靶向标志物KRAS的文献计量学分析。

KRAS是癌症领域备受关注的关键明星基因，本研究旨在综述KRAS的研究热点和发展趋势。在Web of Science Core Collection数据库中检索有关KRAS的出版物。使用VOSviewer 1.6.16和R软件包“bibliometrix”进行文献计量学分析。共确定了23 758份出版物，包括19 325篇原创文章和2913篇评论。通过时间趋势分析发现，自2016年以来，论文发表数量急剧增加。发表论文数量最多的前3个国家/地区分别是美国、中国和欧洲。最活跃的组织来自欧洲和美国。关键词共现分析显示KRAS在癌症特别是胰腺癌发展过程中的作用及分子机制、KRAS在结直肠癌中的特点及临床价值研究、KRAS在肺癌发生中的作用特点及其临床应用、靶向KRAS临床试验的研究进展等4个KRAS聚类。本研究系统地阐明了对关键基因KRAS的新见解，为KRAS驱动的肿瘤发生提供了当代视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer treatment and research communications Medicine-Oncology

CiteScore

4.30

自引率

0.00%

发文量

148

审稿时长

56 days

期刊介绍： Cancer Treatment and Research Communications is an international peer-reviewed publication dedicated to providing comprehensive basic, translational, and clinical oncology research. The journal is devoted to articles on detection, diagnosis, prevention, policy, and treatment of cancer and provides a global forum for the nurturing and development of future generations of oncology scientists. Cancer Treatment and Research Communications publishes comprehensive reviews and original studies describing various aspects of basic through clinical research of all tumor types. The journal also accepts clinical studies in oncology, with an emphasis on prospective early phase clinical trials. Specific areas of interest include basic, translational, and clinical research and mechanistic approaches; cancer biology; molecular carcinogenesis; genetics and genomics; stem cell and developmental biology; immunology; molecular and cellular oncology; systems biology; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; cancer policy; and integration of various approaches. Our mission is to be the premier source of relevant information through promoting excellence in research and facilitating the timely translation of that science to health care and clinical practice.