Enhanced Antibacterial and Anticancer Activities of Vanadium-Doped ZnO Nanoparticles: Effect of Doping Concentration

IF 0.7 4区物理与天体物理 Q4 PHYSICS, MULTIDISCIPLINARY

Bulletin of the Lebedev Physics Institute Pub Date : 2025-09-21 DOI:10.3103/S1068335625602535

M. Divya Gnaneswari, C. Raghavan, L. Bruno Chandrasekar, M. Karunakaran, L. Saravanan, S. Vimal, Saravanan Rajendran, Sonaimuthu Mohandoss, Subramanian Palanisamy, J. Thirumalai, P. Shunmuga Sundaram

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Abstract

Vanadium-doped zinc oxide nanoparticles are synthesized by the hydrothermal method with different doping concentrations. The main objective of the research is to analyze the role of doping concentration against septicemia and human colon cancer. The prepared nanoparticles are extensively characterized by the X-ray diffraction technique. The crystallite size, stain, lattice constants, and bond lengths are examined. The vanadium doping enhances the antibacterial activity against bacterial strains. The in vitro anticancer activity of the prepared nanoparticles is tested by MTT assay, EtBr and DAPI staining. The concentration-dependent enhancement in the antitumor activity is observed in human colon cancer cells by inducing apoptosis. The change in cell morphology and the induction of apoptosis is also observed in our study. This interesting finding will undoubtedly make substantial contributions to developing successful therapeutic agents for septicemia and colon cancer.

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钒掺杂ZnO纳米颗粒增强抗菌和抗癌活性：掺杂浓度的影响

采用水热法制备了不同掺杂浓度的钒氧化锌纳米颗粒。本研究的主要目的是分析兴奋剂浓度对败血症和人类结肠癌的作用。用x射线衍射技术对制备的纳米颗粒进行了广泛的表征。考察了晶体尺寸、染色、晶格常数和键长。钒的掺杂增强了对细菌的抑菌活性。采用MTT法、EtBr法和DAPI染色法检测纳米颗粒的体外抗癌活性。在人结肠癌细胞中，通过诱导细胞凋亡，观察到浓度依赖性的抗肿瘤活性增强。在我们的研究中也观察到细胞形态的变化和凋亡的诱导。这一有趣的发现无疑将为开发成功的败血症和结肠癌治疗剂做出重大贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bulletin of the Lebedev Physics Institute PHYSICS, MULTIDISCIPLINARY-

CiteScore

0.70

自引率

25.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Bulletin of the Lebedev Physics Institute is an international peer reviewed journal that publishes results of new original experimental and theoretical studies on all topics of physics: theoretical physics; atomic and molecular physics; nuclear physics; optics; lasers; condensed matter; physics of solids; biophysics, and others.