Sridharan Raghavan, Elizabeth Litkowski, Aubrey Jensen, Brian Charest, Zeyuan Wang, Qin Hui, Hua-Chang Chen, Mary K Rhee, Aaron Leong, James B Meigs, Leslie Lange, Ethan Lange, Peter Reaven, Adriana Hung, Jin Zhou, Yan V Sun, Lawrence S Phillips
{"title":"Genome-Wide Association Study of Hypoglycemia in Adults With Diabetes in the Million Veteran Program.","authors":"Sridharan Raghavan, Elizabeth Litkowski, Aubrey Jensen, Brian Charest, Zeyuan Wang, Qin Hui, Hua-Chang Chen, Mary K Rhee, Aaron Leong, James B Meigs, Leslie Lange, Ethan Lange, Peter Reaven, Adriana Hung, Jin Zhou, Yan V Sun, Lawrence S Phillips","doi":"10.2337/db25-0304","DOIUrl":null,"url":null,"abstract":"<p><strong>Article highlights: </strong>Genetic variants associated with hypoglycemia risk in individuals with medication-treated diabetes have not been evaluated genome-wide. The specific question we asked was whether common genetic variants are associated with hypoglycemia among individuals with diabetes treated with glucose-lowering medications. We found four genomic loci were associated with hypoglycemia in a genome-wide association study. One locus-on chromosome 6-was associated with hypoglycemia only in individuals with likely type 1 diabetes, and two loci-on chromosome 2 and chromosome 6-were associated with hypoglycemia only in the context of treatment with sulfonylureas (chromosome 2) or with insulin (chromosome 6). Genetic variants may help identify individuals with diabetes at increased hypoglycemia risk, but additional study is needed to address the clinical utility of genetic data to inform hypoglycemia risk.</p>","PeriodicalId":93977,"journal":{"name":"Diabetes","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diabetes","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2337/db25-0304","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Article highlights: Genetic variants associated with hypoglycemia risk in individuals with medication-treated diabetes have not been evaluated genome-wide. The specific question we asked was whether common genetic variants are associated with hypoglycemia among individuals with diabetes treated with glucose-lowering medications. We found four genomic loci were associated with hypoglycemia in a genome-wide association study. One locus-on chromosome 6-was associated with hypoglycemia only in individuals with likely type 1 diabetes, and two loci-on chromosome 2 and chromosome 6-were associated with hypoglycemia only in the context of treatment with sulfonylureas (chromosome 2) or with insulin (chromosome 6). Genetic variants may help identify individuals with diabetes at increased hypoglycemia risk, but additional study is needed to address the clinical utility of genetic data to inform hypoglycemia risk.
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