Improvement of an eye disease detection model by using the denoising diffusion implicit model

IF 3.1 4区 生物学 Q2 BIOLOGY
Ping-Huan Kuo , Eirene Du , Chiou-Jye Huang , Wei-Chuan Lan , Shu-Hung Chou , Ting-Chun Yao , Chao-Chung Peng
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Abstract

With rapid developments in artificial intelligence (AI), the discussion about and applications of generative AI have increased substantially. Generative AI has extensive and valuable applications in many industrial and medical fields and is a possible solution for industries that struggle to collect large quantities of data. The present study evaluated the use of generative AI in eye disease prediction. Because retinal images are difficult to acquire, this study used a generative AI model [i.e., the denoising diffusion implicit model (DDIM)] to conduct data augmentation, thereby improving the accuracy of a convolutional neural network (CNN) model developed for eye disease detection. This study adopted the DDIM primarily for its high inference speed and ability to consistently generate high-quality samples in a limited number of steps, making it suitable for tasks that require high-quality medical images. With the increasing prevalence of electronic products, the number of patients with retinopathy or optic neuropathy is increasing annually, and patients are experiencing these diseases at increasingly younger ages. Moreover, eye diseases such as glaucoma and macular degeneration are becoming increasingly common in modern society. The developed CNN model exhibited a 3 % higher accuracy when it was trained using the data generated by the DDIM than when it was trained without these data. This CNN model can screen eye disease symptoms early to enable patients to receive timely treatment, thereby mitigating the risk and consequences of eye diseases. The results of this study indicate that the training data generated using the DDIM can enhance the accuracy of early eye disease detection.
用去噪扩散隐式模型改进眼病检测模型。
随着人工智能的快速发展,关于生成式人工智能的讨论和应用也越来越多。生成式人工智能在许多工业和医疗领域具有广泛而有价值的应用,是难以收集大量数据的行业的可能解决方案。本研究评估了生成式人工智能在眼病预测中的应用。由于视网膜图像难以获取,本研究采用生成式AI模型[即去噪扩散隐式模型(DDIM)]进行数据增强,从而提高了用于眼病检测的卷积神经网络(CNN)模型的准确性。本研究采用DDIM的主要原因是其高推理速度和在有限的步骤中持续生成高质量样本的能力,使其适合需要高质量医学图像的任务。随着电子产品的日益普及,患有视网膜病变或视神经病变的患者数量每年都在增加,并且患者的年龄越来越小。此外,青光眼和黄斑变性等眼病在现代社会越来越普遍。当使用DDIM生成的数据进行训练时,所开发的CNN模型的准确率比不使用这些数据进行训练时提高了3 %。该CNN模型可以早期筛查眼病症状,使患者得到及时的治疗,从而降低眼病的风险和后果。本研究结果表明,使用DDIM生成的训练数据可以提高早期眼病检测的准确性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Computational Biology and Chemistry
Computational Biology and Chemistry 生物-计算机:跨学科应用
CiteScore
6.10
自引率
3.20%
发文量
142
审稿时长
24 days
期刊介绍: Computational Biology and Chemistry publishes original research papers and review articles in all areas of computational life sciences. High quality research contributions with a major computational component in the areas of nucleic acid and protein sequence research, molecular evolution, molecular genetics (functional genomics and proteomics), theory and practice of either biology-specific or chemical-biology-specific modeling, and structural biology of nucleic acids and proteins are particularly welcome. Exceptionally high quality research work in bioinformatics, systems biology, ecology, computational pharmacology, metabolism, biomedical engineering, epidemiology, and statistical genetics will also be considered. Given their inherent uncertainty, protein modeling and molecular docking studies should be thoroughly validated. In the absence of experimental results for validation, the use of molecular dynamics simulations along with detailed free energy calculations, for example, should be used as complementary techniques to support the major conclusions. Submissions of premature modeling exercises without additional biological insights will not be considered. Review articles will generally be commissioned by the editors and should not be submitted to the journal without explicit invitation. However prospective authors are welcome to send a brief (one to three pages) synopsis, which will be evaluated by the editors.
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