Efficacy of chlorhexidine gluconate of different concentrations in preventing short peripheral catheter-related infections: A double-blind randomized controlled trial.

IF 1.7 3区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of Vascular Access Pub Date : 2025-09-19 DOI:10.1177/11297298251369910

Fatma Cihanger, Nihal Taskiran

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引用次数: 0

Abstract

Objective: Evaluation of the efficacy of different concentrations of chlorhexidine gluconate in the prevention of short peripheral catheter-related infections.

Methods: This randomized controlled study consisted of 96 patients who had short peripheral catheter. Patients were randomly assigned to apply skin antisepsis with either 1%, 2% and 4% chlorhexidine gluconate or 70% isopropyl alcohol. Microbial cultures were collected at the site surrounding catheter insertion before catheterization, within the first and the 96th hours after catheterization to assess microbial growth.

Results: Compared to the pre-catheterization period, the number of Gram (+) bacteria detected at the 96th hour post-catheterization decreased by 76.4% in 1% chlorhexidine gluconate group, 90% in 2% and 4% chlorhexidine gluconate group and 30% in 70% isopropyl alcohol group in the skin swabs.

Conclusions: 2% chlorhexidine gluconate was most effective antiseptic in preventing short peripheral catheter-related infections than other concentrations.

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不同浓度葡萄糖酸氯己定预防短时间外周导管相关感染的疗效：一项双盲随机对照试验

目的：评价不同浓度葡萄糖酸氯己定预防短时间外周导管相关感染的疗效。方法：随机对照研究96例短外周导管患者。患者被随机分配使用1%、2%和4%的葡萄糖酸氯己定或70%异丙醇进行皮肤消毒。在置管前、置管后第1小时和第96小时收集导管周围的微生物培养物，以评估微生物的生长情况。结果：与置管前相比，置管后第96 h， 1%葡萄糖酸氯己定组皮肤拭子中检出的革兰氏（+）细菌数量减少76.4%，2%和4%葡萄糖酸氯己定组减少90%，70%异丙醇组减少30%。结论：2%葡萄糖酸氯己定是预防外周导管相关感染最有效的防腐剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Vascular Access 医学-外周血管病

CiteScore

3.40

自引率

31.60%

发文量

181

审稿时长

6-12 weeks

期刊介绍： The Journal of Vascular Access (JVA) is issued six times per year; it considers the publication of original manuscripts dealing with clinical and laboratory investigations in the fast growing field of vascular access. In addition reviews, case reports and clinical trials are welcome, as well as papers dedicated to more practical aspects covering new devices and techniques. All contributions, coming from all over the world, undergo the peer-review process. The Journal of Vascular Access is divided into independent sections, each led by Editors of the highest scientific level: • Dialysis • Oncology • Interventional radiology • Nutrition • Nursing • Intensive care Correspondence related to published papers is also welcome.