Emerging role of E4BP4/NFIL3 in metabolic homeostasis

IF 11.9 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Shuman Ran , Siqi Wang , Qi Jin , Genzheng Liu , Xiaobin Xue , Peng Qu , Liang Peng , Hua Meng
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引用次数: 0

Abstract

E4BP4/NFIL3 (E4 promoter-binding protein 4 or nuclear factor interleukin-3-regulated protein), is well-established for its association with circadian rhythm regulation and immune function. Recent advances in research have revealed its emerging and indispensable role in metabolic homeostasis, positioning it at the crossroads of circadian biology, immune responses, and metabolic balance. This review summarizes three decades of research on E4BP4/NFIL3 and explores its structural basis and regulatory functions. We synthesized current insights into the regulatory pathways that govern E4BP4/NFIL3 and discuss its central role in various metabolic scenarios, emphasizing its emerging significance as a pivotal metabolic regulator. Finally, we identify critical, unresolved questions and propose future research directions to enhance our understanding of E4BP4/NFIL3's broader implications in metabolic health.

Abstract Image

E4BP4/NFIL3在代谢稳态中的新作用。
E4BP4/NFIL3 (E4启动子结合蛋白4或核因子白介素-3调节蛋白)因其与昼夜节律调节和免疫功能相关而被证实。最近的研究进展表明,它在代谢稳态中发挥着不可或缺的作用,处于昼夜节律生物学、免疫反应和代谢平衡的十字路口。本文综述了近30年来有关E4BP4/NFIL3的研究,并对其结构基础和调控功能进行了探讨。我们综合了目前对E4BP4/NFIL3调控途径的见解,并讨论了其在各种代谢情景中的核心作用,强调了其作为关键代谢调节剂的新意义。最后,我们确定了关键的、未解决的问题,并提出了未来的研究方向,以增强我们对E4BP4/NFIL3在代谢健康中的更广泛影响的理解。
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来源期刊
Metabolism: clinical and experimental
Metabolism: clinical and experimental 医学-内分泌学与代谢
CiteScore
18.90
自引率
3.10%
发文量
310
审稿时长
16 days
期刊介绍: Metabolism upholds research excellence by disseminating high-quality original research, reviews, editorials, and commentaries covering all facets of human metabolism. Consideration for publication in Metabolism extends to studies in humans, animal, and cellular models, with a particular emphasis on work demonstrating strong translational potential. The journal addresses a range of topics, including: - Energy Expenditure and Obesity - Metabolic Syndrome, Prediabetes, and Diabetes - Nutrition, Exercise, and the Environment - Genetics and Genomics, Proteomics, and Metabolomics - Carbohydrate, Lipid, and Protein Metabolism - Endocrinology and Hypertension - Mineral and Bone Metabolism - Cardiovascular Diseases and Malignancies - Inflammation in metabolism and immunometabolism
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