The Morphologic Characteristics of Meibomian Glands in Allergic Conjunctivitis-Related Dry Eye in Children.

IF 3 3区医学 Q2 ALLERGY

Journal of Asthma and Allergy Pub Date : 2025-09-13 eCollection Date: 2025-01-01 DOI:10.2147/JAA.S535595

Xiao-Jiao Tang, Lin Chen, Qing Liu, Yong Li

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引用次数: 0

Abstract

Purpose: To investigate the morphological characteristics of the meibomian glands (MGs) in children with allergic conjunctivitis (AC)-related dry eye (DE).

Methods: Children with a clinical diagnosis of seasonal allergic conjunctivitis (SAC) and perennial allergic conjunctivitis (PAC) were recruited. Age- and sex-matched children without a history of allergy or dry eye were recruited as controls. All participants completed the 5-item Dry Eye Questionnaire (DEQ-5) and ocular surface examination, including assessment of the tear meniscus height (TMH), noninvasive tear breakup time (NIBUT), and morphology of the upper lower MGs by noncontact infrared meibography (Oculus Keratograph 5M). Receiver operating characteristic (ROC) curve analysis was performed to determine the predictive value of the morphological characteristics of the MGs for AC-related DE.

Results: Sixty-two children with AC (31 with DE and 31 without DE) and 33 healthy children were enrolled in the study. The mean age was 7.67 (ranging from 5-13.5) years. More morphological changes were observed in the upper eyelids of AC children with DE than in healthy children. No morphological feature difference was found between AC children without DE and healthy children. ROC curve analysis showed that the morphological characteristics with good predictive value for DE were shortened upper eyelid MGs (AUC=0.72, P<0.001) and hooked upper eyelid MGs (AUC=0.71, P<0.001).

Conclusion: The grading of MG morphology according to the DREAM Study may be a valuable predictor for AC-related DE in children.

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儿童变应性结膜炎干眼症睑板腺的形态学特征。

目的：探讨过敏性结膜炎干眼（DE）患儿睑板腺（mg）的形态学特征。方法：选取临床诊断为季节性变应性结膜炎（SAC）和常年性变应性结膜炎（PAC）的患儿为研究对象。年龄和性别匹配的无过敏史或干眼症的儿童被招募作为对照。所有参与者完成了干眼问卷（DEQ-5）和眼表检查，包括泪液半月板高度（TMH）、无创泪液破裂时间（NIBUT）和非接触式红外微影记录仪（Oculus Keratograph 5M）评估上、下mg的形态。采用受试者工作特征（ROC）曲线分析，确定mg形态学特征对AC相关DE的预测价值。结果：共纳入62例AC患儿（合并DE 31例，未合并DE 31例）和33例健康儿童。平均年龄7.67岁（5 ~ 13.5岁）。AC合并DE的儿童上眼睑的形态学改变多于健康儿童。无DE的AC儿童与健康儿童的形态学特征无差异。ROC曲线分析显示，缩短的上眼睑MG形态特征对DE有较好的预测价值（AUC=0.72, p）。结论：DREAM研究中MG形态的分级可能是预测儿童ac相关性DE的一个有价值的指标。

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来源期刊

Journal of Asthma and Allergy Medicine-Immunology and Allergy

CiteScore

5.30

自引率

6.20%

发文量

185

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed journal publishing original research, reports, editorials and commentaries on the following topics: Asthma; Pulmonary physiology; Asthma related clinical health; Clinical immunology and the immunological basis of disease; Pharmacological interventions and new therapies. Although the main focus of the journal will be to publish research and clinical results in humans, preclinical, animal and in vitro studies will be published where they shed light on disease processes and potential new therapies.