Synthetic MRI as a T2WI alternative in bp-MRI: comparable image quality and improved PI-RADS performance

IF 3.3 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology Pub Date : 2025-09-10 DOI:10.1016/j.ejrad.2025.112414

You Yun , Jinxia Guo , Nannan Shao , Xiaoxian Zhang , Lifeng Wang , Wentao Liu , Yue Wu , Chunmiao Xu , Renzhi Zhang , Xuejun Chen

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引用次数: 0

Abstract

Objectives

Prostate cancer significantly impacts men’s health, highlighting the necessity for precise diagnosis. This study evaluates combining Magnetic Resonance Image Compilation (MAGiC) parameters with Prostate Imaging Reporting and Data System (PI-RADS) scores to enhance diagnostic accuracy among radiologists with varied experience.

Methods

In this retrospective study, 174 patients with suspected prostate cancer were recruited from February 2023 to May 2024. Synthetic MRI-derived T1, T2, and proton density (PD) maps were generated, and synthetic T2-weighted imaging (T2WI) was reconstructed. Two radiologists of varying experience independently assessed lesions using PI-RADS based on both synthetic and conventional T2WI. Image quality was evaluated using the prostate imaging quality (PI-QUAL) scoring v2 system, and diagnostic performance was analyzed using receiver operating characteristic (ROC) curve analysis.

Results

Synthetic T2WI exhibited comparable image quality to conventional T2WI (P = 0.065). After excluding low-quality images, 99 lesions were analyzed. In the peripheral zone, higher T1 values were significantly linked to non-cancerous lesions (R1: OR = 0.989, P = 0.009; R2: OR = 0.990, P = 0.004). The integration of T1 values with PI-RADS scores improved diagnostic performance, achieving area under the curve (AUC) values of 0.960 for R1 and 0.944 for R2.

Conclusion

The integration of MAGiC parameters, particularly T1 values, with PI-RADS scores significantly enhances diagnostic accuracy for clinically significant prostate cancer, especially benefitting less experienced radiologists. Additionally, synthetic T2WI demonstrates comparable image quality to conventional T2WI, supporting the clinical implementation of MAGiC parameters in prostate MRI assessments.

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合成MRI作为bp-MRI的T2WI替代：可媲美的图像质量和改进的PI-RADS性能。

目的：前列腺癌显著影响男性健康，强调准确诊断的必要性。本研究评估了将磁共振图像汇编（MAGiC）参数与前列腺成像报告和数据系统（PI-RADS）评分相结合，以提高具有不同经验的放射科医生的诊断准确性。方法：在这项回顾性研究中，从2023年2月至2024年5月招募了174例疑似前列腺癌患者。生成合成mri衍生的T1、T2和质子密度（PD）图，并重建合成T2加权成像（T2WI）。两名不同经验的放射科医生在合成和常规T2WI的基础上使用PI-RADS独立评估病变。采用前列腺成像质量（PI-QUAL）评分v2系统评价图像质量，采用受试者工作特征（ROC）曲线分析诊断效果。结果：合成T2WI图像质量与常规T2WI相当（P = 0.065）。在排除低质量图像后，分析了99个病变。在外周区，较高的T1值与非癌性病变显著相关（R1: OR = 0.989, P = 0.009; R2: OR = 0.990, P = 0.004）。T1值与PI-RADS评分的整合提高了诊断效能，曲线下面积（AUC）值在R1和R2下分别为0.960和0.944。结论：MAGiC参数，特别是T1值与PI-RADS评分的整合显著提高了对临床意义显著的前列腺癌的诊断准确性，尤其使经验不足的放射科医生受益。此外，合成T2WI显示出与传统T2WI相当的图像质量，支持MAGiC参数在前列腺MRI评估中的临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Radiology 医学-核医学

CiteScore

6.70

自引率

3.00%

发文量

398

审稿时长

42 days

期刊介绍： European Journal of Radiology is an international journal which aims to communicate to its readers, state-of-the-art information on imaging developments in the form of high quality original research articles and timely reviews on current developments in the field. Its audience includes clinicians at all levels of training including radiology trainees, newly qualified imaging specialists and the experienced radiologist. Its aim is to inform efficient, appropriate and evidence-based imaging practice to the benefit of patients worldwide.