Application of Physiologically Based Pharmacokinetic Modeling in the Research of Anti-HIV Drugs.

IF 1.8 4区医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current drug metabolism Pub Date : 2025-09-17 DOI:10.2174/0113892002392579250902053006

Yuewu Xie, Wenting Zhang, Huilong Wang, Haifeng Hu, Shengpeng Zhang, Shaozhen Wang, Jun Han

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引用次数: 0

Abstract

Physiologically based pharmacokinetic (PBPK) modeling is a computational technique that uses the physicochemical properties of drugs and physiological information to simulate plasma and tissue concen-trations. PBPK modeling has become a mainstream approach in drug research and development, frequently employed to support regulatory packages for new drug applications. Understanding the pharmacokinetic char-acteristics of anti-HIV drugs is essential for successful treatment. In recent decades, PBPK modeling has been commonly used in the development and clinical therapy of anti-HIV medications. This review discusses the prevalence and application of PBPK modeling in the pharmacokinetics of anti-HIV drugs. Among the articles retrieved for this review, PBPK modeling was predominantly employed for anti-HIV drugs in contexts, such as pregnancy, drug-drug interactions, and pediatrics. The most commonly used software programs for this model are Simcyp, MATLAB, and PK-sim. This review will provide insights for researchers in applying PBPK models to manage patients with HIV infection, aiming to enhance the efficacy of anti-HIV drug therapy and prevent undesirable adverse effects.

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基于生理的药代动力学建模在抗hiv药物研究中的应用。

基于生理的药代动力学（PBPK）建模是一种利用药物的物理化学性质和生理信息来模拟血浆和组织浓度的计算技术。PBPK建模已成为药物研究和开发的主流方法，经常用于支持新药应用的监管包。了解抗hiv药物的药代动力学特征对成功治疗至关重要。近几十年来，PBPK模型已广泛用于抗hiv药物的开发和临床治疗。本文综述了PBPK模型在抗hiv药物药代动力学中的应用。在本综述检索到的文章中，PBPK模型主要用于抗hiv药物，如妊娠、药物-药物相互作用和儿科。该模型最常用的软件程序是Simcyp、MATLAB和PK-sim。本综述将为研究人员应用PBPK模型管理HIV感染患者提供参考，旨在提高抗HIV药物治疗的疗效，防止不良反应的发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug metabolism 医学-生化与分子生物学

CiteScore

4.30

自引率

4.30%

发文量

审稿时长

4-8 weeks

期刊介绍： Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism. More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.