The associations between glucose, inflammation, cognitive functions, and white matter structural connectivity in euthymic bipolar patients

IF 7.6 2区医学 Q1 IMMUNOLOGY

Brain, Behavior, and Immunity Pub Date : 2025-09-16 DOI:10.1016/j.bbi.2025.106109

Wei Hung Chang , Tsung-Hua Lu , Van San Bui , Hui Hua Chang , Jun-Cheng Weng , Shih-Hsien Lin , Shyh-Yuh Wei , Huai-Hsuan Tseng , Po See Chen

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引用次数: 0

Abstract

Background

Previous studies have shown that human white matter structural connectivity is independently associated with glucose metabolism, inflammation, and cognitive function. However, an integrative understanding of these relationships in bipolar disorder (BD) remains unclear.

Methods

This study included 44 euthymic patients with BD and 59 healthy controls (HCs). White matter structural connectivity was assessed using diffusion tensor imaging (DTI). Metabolic parameters, including fasting glucose and high-sensitivity C-reactive protein (hsCRP), were measured. Cognitive function was evaluated using the Wisconsin Card Sorting Test (WCST).

Results

DTI analysis revealed that BD patients had significantly higher gamma (46.52 ± 2.89 vs. 45.21 ± 2.95, p = 0.026) and sigma (41.73 ± 2.30 vs. 40.58 ± 2.40, p = 0.016) metrics compared to HCs after adjusting for age, years of education, and body mass index. In the BD group, the gamma and sigma metrics of DTI showed significantly negative correlations with the total number of categories completed in the WCST. Furthermore, in BD patients, both gamma and sigma metrics were positively correlated with fasting glucose and hsCRP levels.

Conclusions

Cognitive deficits in patients with BD may be linked to over-segregated neuronal activities, as indicated by elevated gamma DTI metrics. These abnormalities appear to be associated with higher levels of inflammation and glucose metabolism.

查看原文本刊更多论文

健郁双相患者血糖、炎症、认知功能和白质结构连通性之间的关系。

背景：已有研究表明，人类白质结构连通性与糖代谢、炎症和认知功能独立相关。然而，对双相情感障碍（BD）中这些关系的综合理解仍不清楚。方法：本研究纳入44例健康BD患者和59例健康对照（hc）。采用扩散张量成像（DTI）评估白质结构连通性。测量代谢参数，包括空腹血糖和高敏c反应蛋白（hsCRP）。采用威斯康辛卡片分类测验（WCST）评估认知功能。结果:DTI分析显示,双相障碍患者明显高于γ( 46.52±2.89 vs 45.21  ± 2.95,p = 0.026)和标准差(41.73 ±2.30 vs 40.58  ± 2.40,p = 0.016)指标相比,高碳钢在调整了年龄,多年的教育,和身体质量指数。在BD组中，DTI的gamma和sigma指标与WCST中完成的类别总数呈显著负相关。此外，在BD患者中，gamma和sigma指标与空腹血糖和hsCRP水平呈正相关。结论：正如伽马DTI指标升高所表明的那样，双相障碍患者的认知缺陷可能与过度分离的神经元活动有关。这些异常似乎与较高水平的炎症和葡萄糖代谢有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain, Behavior, and Immunity 医学-免疫学

CiteScore

29.60

自引率

2.00%

发文量

290

审稿时长

28 days

期刊介绍： Established in 1987, Brain, Behavior, and Immunity proudly serves as the official journal of the Psychoneuroimmunology Research Society (PNIRS). This pioneering journal is dedicated to publishing peer-reviewed basic, experimental, and clinical studies that explore the intricate interactions among behavioral, neural, endocrine, and immune systems in both humans and animals. As an international and interdisciplinary platform, Brain, Behavior, and Immunity focuses on original research spanning neuroscience, immunology, integrative physiology, behavioral biology, psychiatry, psychology, and clinical medicine. The journal is inclusive of research conducted at various levels, including molecular, cellular, social, and whole organism perspectives. With a commitment to efficiency, the journal facilitates online submission and review, ensuring timely publication of experimental results. Manuscripts typically undergo peer review and are returned to authors within 30 days of submission. It's worth noting that Brain, Behavior, and Immunity, published eight times a year, does not impose submission fees or page charges, fostering an open and accessible platform for scientific discourse.