Protective effects of Elaeagnus angustifolia L. fruit extract on CCl₄-induced oxidative stress and inflammation in rats liver.

IF 2.2 Q3 CHEMISTRY, MEDICINAL

Avicenna Journal of Phytomedicine Pub Date : 2025-09-01 DOI:10.22038/ajp.2025.25915

Masoud Ojarudi, Ali Golchin, Hamid Reza Karamdel, Mohammad Valilo, Parviz Ranjbarvan

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Abstract

Objective: Hepatic cells face oxidative stress-induced damage, but plant antioxidants may offer protection. This study aimed to assess Elaeagnus angustifolia L. fruit extract's potential in shielding rat livers from CCl₄ damage.

Materials and methods: 30 Male Wistar rats were randomly divided into five groups: normal control (received distilled water), E. angustifolia hydroalcoholic extract control, CCl₄ control, E. angustifolia extract pretreatment (600 mg/kg), and silymarin pretreatment (100 mg/kg). After 14 days of oral administration of extracts, CCl₄ was injected intraperitoneally. The samples were collected 48 hr later. Histological and biochemical analyses were then carried out.

Results: CCl₄ injection caused significant (p<0.001) changes in liver serum enzymes, lipid profile, bilirubin, total protein, serum albumin, antioxidant enzymes, malondialdehyde, Inflammatory cytokines, and liver tissue morphology. E . angustifolia extract pre-treatment significantly (p<0.05) returned changes to the normal state.

Conclusion: This study's findings revealed that E. angustifolia extract pretreatment could reduce liver injury caused by CCl₄ in rats.

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榆果提取物对ccl4诱导的大鼠肝脏氧化应激和炎症的保护作用。

目的：肝细胞面临氧化应激诱导的损伤，而植物抗氧化剂可能提供保护。本研究旨在探讨沙枣果实提取物对CCl4损伤大鼠肝脏的保护作用。材料与方法：将30只雄性Wistar大鼠随机分为5组：正常对照组（给予蒸馏水）、金针叶水醇提取物对照组、CCl4对照组、金针叶提取物预处理（600 mg/kg）、水飞蓟素预处理（100 mg/kg）。口服提取物14天后，腹腔注射CCl4。48小时后采集样本。然后进行组织学和生化分析。结果：注射CCl4引起明显的pE。结论：本研究结果表明，金针叶提取物预处理可减轻CCl4对大鼠肝损伤的影响。

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