Tetrasodium EDTA central venous catheter lock solution in home parenteral nutrition patients: Ease of use and patient satisfaction, a prospective study.

IF 1.7 3区医学 Q3 PERIPHERAL VASCULAR DISEASE

Journal of Vascular Access Pub Date : 2025-09-17 DOI:10.1177/11297298251376970

Lina Saucedo, Yasaman Ghorbani, Maria Heusser, Giulia Chagas, Celeste Arca, Katherine J P Schwenger, Johane P Allard

{"title":"Tetrasodium EDTA central venous catheter lock solution in home parenteral nutrition patients: Ease of use and patient satisfaction, a prospective study.","authors":"Lina Saucedo, Yasaman Ghorbani, Maria Heusser, Giulia Chagas, Celeste Arca, Katherine J P Schwenger, Johane P Allard","doi":"10.1177/11297298251376970","DOIUrl":null,"url":null,"abstract":"Objective: Chronic intestinal failure is a devastating chronic medical condition, which requires central venous access for parenteral nutrition infusion. The presence of a central venous line is associated with an increased risk of bloodstream infection and thrombosis. Currently, the heparin lock is the most used catheter lock, but still has risks for line infection. The 4% tetrasodium EDTA catheter lock (KiteLock™) solution, has demonstrated a decrease in infection and thrombosis risk, but requires extra steps for the preparation and infusion. The objective of this study was to evaluate the patients ease-of-use and acceptability of the new KiteLock solution in the home parenteral nutrition (HPN) patients.Methods: This prospective, open-label, single-center study evaluated patient acceptability of tetrasodium EDTA (KiteLock) in HPN. Patients were contacted four times, beginning with an instructional visit by the HPN nurse. They then completed three 30-day phases: standard heparin/saline flush, tetrasodium with withdrawal (when feasible), and tetrasodium EDTA. During the final week of each phase, patients completed a phone survey and questionnaire with the HPN nurse.Results: Of the 21 patients enrolled, 14 completed the study. Seven did not: two withdrew due to time constraints, two found KiteLock difficult to infuse, and three had incomplete data. Among those who competed the study, some reported reduced ease-of-use with KiteLock (1 hard to open, 5 difficulties withdrawing, 1 overall difficulty), though most still rated it easy or very easy. Three patients continued to find it more difficult by study end. No adverse effects were reported. Preparation time decreased over time as patients adapted. Initial satisfaction with KiteLock was lower (50% find it neutral), but improved with familiarity, becoming comparable to heparin with 12 patients satisfied (N = 14).Conclusions: KiteLock solution is well accepted by the patient or caregiver, despite involving more steps to use it.","PeriodicalId":56113,"journal":{"name":"Journal of Vascular Access","volume":" ","pages":"11297298251376970"},"PeriodicalIF":1.7000,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Vascular Access","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/11297298251376970","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: Chronic intestinal failure is a devastating chronic medical condition, which requires central venous access for parenteral nutrition infusion. The presence of a central venous line is associated with an increased risk of bloodstream infection and thrombosis. Currently, the heparin lock is the most used catheter lock, but still has risks for line infection. The 4% tetrasodium EDTA catheter lock (KiteLock™) solution, has demonstrated a decrease in infection and thrombosis risk, but requires extra steps for the preparation and infusion. The objective of this study was to evaluate the patients ease-of-use and acceptability of the new KiteLock solution in the home parenteral nutrition (HPN) patients.

Methods: This prospective, open-label, single-center study evaluated patient acceptability of tetrasodium EDTA (KiteLock) in HPN. Patients were contacted four times, beginning with an instructional visit by the HPN nurse. They then completed three 30-day phases: standard heparin/saline flush, tetrasodium with withdrawal (when feasible), and tetrasodium EDTA. During the final week of each phase, patients completed a phone survey and questionnaire with the HPN nurse.

Results: Of the 21 patients enrolled, 14 completed the study. Seven did not: two withdrew due to time constraints, two found KiteLock difficult to infuse, and three had incomplete data. Among those who competed the study, some reported reduced ease-of-use with KiteLock (1 hard to open, 5 difficulties withdrawing, 1 overall difficulty), though most still rated it easy or very easy. Three patients continued to find it more difficult by study end. No adverse effects were reported. Preparation time decreased over time as patients adapted. Initial satisfaction with KiteLock was lower (50% find it neutral), but improved with familiarity, becoming comparable to heparin with 12 patients satisfied (N = 14).

Conclusions: KiteLock solution is well accepted by the patient or caregiver, despite involving more steps to use it.

查看原文本刊更多论文

EDTA四钠中心静脉导管锁定溶液在家庭肠外营养患者中的应用：易用性和患者满意度，一项前瞻性研究。

目的：慢性肠衰竭是一种破坏性的慢性疾病，需要通过中心静脉进行肠外营养输注。中心静脉线的存在与血流感染和血栓形成的风险增加有关。目前，肝素锁是使用最多的导管锁，但仍存在管路感染的风险。4%四钠EDTA导管锁定（KiteLock™）溶液已证明可降低感染和血栓形成风险，但需要额外的制备和输注步骤。本研究的目的是评估新的KiteLock溶液在家庭肠外营养（HPN）患者中的易用性和可接受性。方法：这项前瞻性、开放标签、单中心研究评估了HPN患者对四钠EDTA （KiteLock）的可接受性。患者被联系了四次，从HPN护士的指导访问开始。然后，他们完成了三个为期30天的阶段：标准肝素/生理盐水冲洗，停用四钠（可行时）和EDTA四钠。在每个阶段的最后一周，患者与HPN护士完成电话调查和问卷调查。结果：在21例入组患者中，14例完成了研究。7个没有：2个因时间限制退出，2个发现KiteLock难以注入，3个数据不完整。在参加这项研究的人中，一些人报告说KiteLock的易用性降低了（1个难以打开，5个难以取出，1个总体难度），尽管大多数人仍然认为它很容易或非常容易。三名患者在研究结束时仍然觉得更加困难。无不良反应报告。准备时间随着患者的适应而减少。KiteLock的初始满意度较低（50%认为中性），但随着熟悉程度的提高，与肝素相当，有12名患者满意（N = 14）。结论：KiteLock溶液被患者或护理人员很好地接受，尽管需要更多的步骤来使用它。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Vascular Access 医学-外周血管病

CiteScore

3.40

自引率

31.60%

发文量

181

审稿时长

6-12 weeks

期刊介绍： The Journal of Vascular Access (JVA) is issued six times per year; it considers the publication of original manuscripts dealing with clinical and laboratory investigations in the fast growing field of vascular access. In addition reviews, case reports and clinical trials are welcome, as well as papers dedicated to more practical aspects covering new devices and techniques. All contributions, coming from all over the world, undergo the peer-review process. The Journal of Vascular Access is divided into independent sections, each led by Editors of the highest scientific level: • Dialysis • Oncology • Interventional radiology • Nutrition • Nursing • Intensive care Correspondence related to published papers is also welcome.