Histological types of invasive breast cancer in 830,000 women diagnosed in England during 1988–2016

IF 3.7 2区 医学 Q1 PATHOLOGY
Jake Probert, John Broggio, Sarah C Darby, David Dodwell, Paul McGale, Carolyn Taylor, Kezia Gaitskell
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引用次数: 0

Abstract

Breast cancer can be categorised into a number of histological types, based on microscopic appearances. There is some evidence that the different breast cancer histological types are associated with different patient and tumour characteristics, but few previous studies have been large enough to investigate this systematically, especially for rare histological types. National cancer registration data were used to describe trends in the incidence of specific histological types of invasive breast cancer in women diagnosed when aged 18–89 years in England from January 1988 to December 2016, and to investigate associations between breast cancer histological types and patient and tumour characteristics. There were 838,776 women diagnosed with a first primary invasive breast cancer in this 29-year period, including 614,698 (73%) cases of ductal carcinoma NST [no special type (NST)], 90,028 (11%) cases of lobular carcinoma, and more than 16,000 (2%) cases each of tubular and mucinous carcinomas. Rarer histological types included medullary, papillary, metaplastic, and cribriform carcinomas, with >1000 cases of each type. Data quality and completeness improved substantially during the study period. The different histological types of breast cancer showed different patterns in incidence by calendar period of diagnosis, age at diagnosis, and screen-detection status, as well as different associations with tumour characteristics such as grade, stage at diagnosis, and molecular subtype. This large nationwide study provides an overview of the changing incidence of the different histological types of invasive breast cancer in England over almost 30 years. It also gives an opportunity to investigate the characteristics of rare histological types, which smaller studies have been unable to explore. In addition, the results demonstrate the continuing value of histological types defined by microscopic morphology, alongside newer molecular classifications.

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1988-2016年英国83万名女性浸润性乳腺癌的组织学类型
根据显微镜下的表现,乳腺癌可分为多种组织学类型。有一些证据表明,不同的乳腺癌组织类型与不同的患者和肿瘤特征有关,但之前的研究很少有足够大的规模来系统地研究这一点,特别是对罕见的组织类型。使用国家癌症登记数据来描述1988年1月至2016年12月期间英格兰18-89岁诊断为浸润性乳腺癌的特定组织学类型的发病率趋势,并调查乳腺癌组织学类型与患者和肿瘤特征之间的关系。在这29年期间,有838776名女性被诊断为原发性浸润性乳腺癌,其中614698例(73%)为导管癌(无特殊类型(NST)), 9028例(11%)为小叶癌,16000多例(2%)为管状癌和粘液癌。罕见的组织学类型包括髓样癌、乳头状癌、化生癌和筛状癌,每种类型约有1000例。在研究期间,数据质量和完整性显著提高。不同组织学类型的乳腺癌在诊断日历期、诊断年龄和筛查检测状态的发生率上表现出不同的模式,并且与肿瘤特征(如分级、诊断分期和分子亚型)有不同的关联。这项全国性的大型研究概述了近30年来英国不同组织学类型浸润性乳腺癌发病率的变化。它也提供了一个机会来研究罕见的组织学类型的特征,这是较小的研究无法探索的。此外,结果证明了显微形态学定义的组织学类型的持续价值,以及更新的分子分类。
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来源期刊
Journal of Pathology Clinical Research
Journal of Pathology Clinical Research Medicine-Pathology and Forensic Medicine
CiteScore
7.40
自引率
2.40%
发文量
47
审稿时长
20 weeks
期刊介绍: The Journal of Pathology: Clinical Research and The Journal of Pathology serve as translational bridges between basic biomedical science and clinical medicine with particular emphasis on, but not restricted to, tissue based studies. The focus of The Journal of Pathology: Clinical Research is the publication of studies that illuminate the clinical relevance of research in the broad area of the study of disease. Appropriately powered and validated studies with novel diagnostic, prognostic and predictive significance, and biomarker discover and validation, will be welcomed. Studies with a predominantly mechanistic basis will be more appropriate for the companion Journal of Pathology.
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