Modulation of Stem Cell Survival and Engraftment: Implications for Stem Cell-Based Therapy.

IF 13.3 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Theranostics Pub Date : 2025-08-11 eCollection Date: 2025-01-01 DOI:10.7150/thno.120805
Qingwen Xu, Chaochao Zhang, Xinyu Liu, Yuyao Sun, Bowei Li, Sihui Nian, Yan Wang, Chenggong Yu
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引用次数: 0

Abstract

Stem cell transplantation holds promise for the treatment of degenerative diseases, tissue injuries, and malignancies. Despite this potential, clinical outcomes have often fallen short, largely due to limited survival and engraftment of transplanted cells at target sites. Recent research efforts have focused on optimizing cell-based therapies through improved understanding of stem cell biology and responsiveness to environmental cues. Emerging evidence indicates that the hostile post-transplantation microenvironment contributes to irreversible cellular damage and death, driven by metabolic dysfunction, immune-mediated responses, reactive oxygen species (ROS), altered biomechanical rigidity, and disrupted intercellular communication. To address these challenges, various strategies have been explored, including supplementation with exogenous metabolic substrates, enhancement of vascular remodeling, administration of antioxidants, and the application of three-dimensional (3D) stem cell spheroids. This review synthesizes current approaches aimed at improving cell viability and therapeutic efficacy in regenerative medicine.

Abstract Image

Abstract Image

Abstract Image

干细胞存活和植入的调节:对干细胞治疗的启示。
干细胞移植有望治疗退行性疾病、组织损伤和恶性肿瘤。尽管有这种潜力,但临床结果往往不足,这主要是由于移植细胞在靶部位的存活和植入有限。最近的研究工作主要集中在通过提高对干细胞生物学和对环境线索的反应性的理解来优化基于细胞的治疗。新出现的证据表明,在代谢功能障碍、免疫介导反应、活性氧(ROS)、生物力学刚度改变和细胞间通讯中断的驱动下,移植后的恶劣微环境会导致不可逆的细胞损伤和死亡。为了应对这些挑战,研究人员探索了各种策略,包括补充外源性代谢底物、增强血管重塑、抗氧化剂管理和三维干细胞球体的应用。本文综述了目前再生医学中旨在提高细胞活力和治疗效果的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Theranostics
Theranostics MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
25.40
自引率
1.60%
发文量
433
审稿时长
1 months
期刊介绍: Theranostics serves as a pivotal platform for the exchange of clinical and scientific insights within the diagnostic and therapeutic molecular and nanomedicine community, along with allied professions engaged in integrating molecular imaging and therapy. As a multidisciplinary journal, Theranostics showcases innovative research articles spanning fields such as in vitro diagnostics and prognostics, in vivo molecular imaging, molecular therapeutics, image-guided therapy, biosensor technology, nanobiosensors, bioelectronics, system biology, translational medicine, point-of-care applications, and personalized medicine. Encouraging a broad spectrum of biomedical research with potential theranostic applications, the journal rigorously peer-reviews primary research, alongside publishing reviews, news, and commentary that aim to bridge the gap between the laboratory, clinic, and biotechnology industries.
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