The association between cadmium exposure and the risk of early liver disease: A systematic review and meta-analysis

IF 3.5 4区医学 Q1 MEDICINE, LEGAL

Regulatory Toxicology and Pharmacology Pub Date : 2025-09-15 DOI:10.1016/j.yrtph.2025.105942

Hualing Zhang , Yue Jing , Lan Guan , Jianlan Luo , Ming Zeng

{"title":"The association between cadmium exposure and the risk of early liver disease: A systematic review and meta-analysis","authors":"Hualing Zhang , Yue Jing , Lan Guan , Jianlan Luo , Ming Zeng","doi":"10.1016/j.yrtph.2025.105942","DOIUrl":null,"url":null,"abstract":"<div><div>Currently, liver diseases are considered to be one of the most prevalent diseases that jeopardize people's health. Existing studies have found that heavy metal cadmium (Cadmium, Cd) exposure is associated with liver disease, but the results of studies on the risk of cadmium on liver disease are inconsistent. In order to further investigate the relationship between cadmium exposure and the risk of early liver disease in the population, this study was conducted by searching PubMed, Cochrane Library, Web of Science, CNKI and Wanfang databases and performing meta-analysis of the relevant literature, so as to systematically evaluate the effect of cadmium exposure on the risk of liver disease. A total of 5201 relevant articles were retrieved. Based on inclusion and exclusion criteria, 25 articles were included in the meta-analysis. Review Manager 5.4 was used for quality assessment, with most studies rated as low risk of bias. Heterogeneity testing showed significant results (<em>P</em> < 0.05). Meta-analysis showed that cadmium exposure increased the risk of elevated liver enzymes (OR = 1.38, 95 % CI: 1.27–1.50), MAFLD (OR = 1.14, 95 % CI: 1.07–1.22) and liver fibrosis (OR = 1.39, 95 % CI: 1.14–1.70). Sensitivity analysis and publication bias detection indicated that the results were reliable. Therefore, the conclusion of this study is that environmental cadmium exposure increases the risk of liver disease, and the extent and dose of cadmium exposure in the population should be further controlled.</div></div>","PeriodicalId":20852,"journal":{"name":"Regulatory Toxicology and Pharmacology","volume":"163 ","pages":"Article 105942"},"PeriodicalIF":3.5000,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Regulatory Toxicology and Pharmacology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0273230025001746","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MEDICINE, LEGAL","Score":null,"Total":0}

引用次数: 0

Abstract

Currently, liver diseases are considered to be one of the most prevalent diseases that jeopardize people's health. Existing studies have found that heavy metal cadmium (Cadmium, Cd) exposure is associated with liver disease, but the results of studies on the risk of cadmium on liver disease are inconsistent. In order to further investigate the relationship between cadmium exposure and the risk of early liver disease in the population, this study was conducted by searching PubMed, Cochrane Library, Web of Science, CNKI and Wanfang databases and performing meta-analysis of the relevant literature, so as to systematically evaluate the effect of cadmium exposure on the risk of liver disease. A total of 5201 relevant articles were retrieved. Based on inclusion and exclusion criteria, 25 articles were included in the meta-analysis. Review Manager 5.4 was used for quality assessment, with most studies rated as low risk of bias. Heterogeneity testing showed significant results (P < 0.05). Meta-analysis showed that cadmium exposure increased the risk of elevated liver enzymes (OR = 1.38, 95 % CI: 1.27–1.50), MAFLD (OR = 1.14, 95 % CI: 1.07–1.22) and liver fibrosis (OR = 1.39, 95 % CI: 1.14–1.70). Sensitivity analysis and publication bias detection indicated that the results were reliable. Therefore, the conclusion of this study is that environmental cadmium exposure increases the risk of liver disease, and the extent and dose of cadmium exposure in the population should be further controlled.

查看原文本刊更多论文

镉暴露与早期肝病风险之间的关系：一项系统综述和荟萃分析。

目前，肝脏疾病被认为是危害人类健康的最普遍的疾病之一。已有研究发现重金属镉（cadmium, Cd）暴露与肝脏疾病有关，但有关镉对肝脏疾病风险的研究结果并不一致。为了进一步探讨镉暴露与人群早期肝病风险的关系，本研究通过检索PubMed、Cochrane Library、Web of Science、CNKI和万方等数据库，并对相关文献进行meta分析，系统评价镉暴露对人群早期肝病风险的影响。共检索到5201篇相关文章。根据纳入和排除标准，25篇文章被纳入meta分析。使用Review Manager 5.4进行质量评估，大多数研究被评为低偏倚风险。异质性检验结果有显著性差异（P < 0.05）。荟萃分析显示，镉暴露增加了肝酶升高（OR=1.38, 95% CI: 1.27-1.50）、MAFLD （OR=1.14, 95% CI: 1.07-1.22）和肝纤维化（OR=1.39, 95% CI: 1.14-1.70）的风险。敏感性分析和发表偏倚检测表明结果是可靠的。因此，本研究的结论是环境镉暴露会增加肝脏疾病的风险，人群中镉暴露的程度和剂量应进一步控制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Regulatory Toxicology and Pharmacology 医学-毒理学

CiteScore

6.70

自引率

8.80%

发文量

147

审稿时长

58 days

期刊介绍： Regulatory Toxicology and Pharmacology publishes peer reviewed articles that involve the generation, evaluation, and interpretation of experimental animal and human data that are of direct importance and relevance for regulatory authorities with respect to toxicological and pharmacological regulations in society. All peer-reviewed articles that are published should be devoted to improve the protection of human health and environment. Reviews and discussions are welcomed that address legal and/or regulatory decisions with respect to risk assessment and management of toxicological and pharmacological compounds on a scientific basis. It addresses an international readership of scientists, risk assessors and managers, and other professionals active in the field of human and environmental health. Types of peer-reviewed articles published: -Original research articles of relevance for regulatory aspects covering aspects including, but not limited to: 1.Factors influencing human sensitivity 2.Exposure science related to risk assessment 3.Alternative toxicological test methods 4.Frameworks for evaluation and integration of data in regulatory evaluations 5.Harmonization across regulatory agencies 6.Read-across methods and evaluations -Contemporary Reviews on policy related Research issues -Letters to the Editor -Guest Editorials (by Invitation)