{"title":"Exploring the nanobody patent landscape: a focus on BCMA sequences and structural analysis.","authors":"Jiaqi Xu, Yan Wang, Ni Yuan, Guang Hu, Yuanjia Hu","doi":"10.1080/19420862.2025.2560893","DOIUrl":null,"url":null,"abstract":"<p><p>Nanobodies (Nbs) are antigen-binding fragments derived from unique heavy-chain-only antibodies. In recent years, the development of Nbs has progressed rapidly due to their therapeutic potential. Here we present a comprehensive patent landscape of Nb technologies, focusing on uncovering innovation trends, identifying novel drug candidates, and analyzing opportunities and challenges for research, development, and commercialization. Using B-cell maturation antigen (BCMA) as an example drug target, we summarize the features, physicochemical properties, modification sites, and epitope-binding tendencies of patented sequences of Nb drugs, highlighting the importance of structural-level patent protection, and offering a theoretical foundation for Nb design and experimental validation. Through patent landscape and patent sequence analysis, our study provides valuable insights for Nb drug development and supports decision-making in patent strategy.</p>","PeriodicalId":18206,"journal":{"name":"mAbs","volume":"17 1","pages":"2560893"},"PeriodicalIF":7.3000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12452430/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"mAbs","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/19420862.2025.2560893","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/9/18 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
引用次数: 0
Abstract
Nanobodies (Nbs) are antigen-binding fragments derived from unique heavy-chain-only antibodies. In recent years, the development of Nbs has progressed rapidly due to their therapeutic potential. Here we present a comprehensive patent landscape of Nb technologies, focusing on uncovering innovation trends, identifying novel drug candidates, and analyzing opportunities and challenges for research, development, and commercialization. Using B-cell maturation antigen (BCMA) as an example drug target, we summarize the features, physicochemical properties, modification sites, and epitope-binding tendencies of patented sequences of Nb drugs, highlighting the importance of structural-level patent protection, and offering a theoretical foundation for Nb design and experimental validation. Through patent landscape and patent sequence analysis, our study provides valuable insights for Nb drug development and supports decision-making in patent strategy.
期刊介绍：
mAbs is a multi-disciplinary journal dedicated to the art and science of antibody research and development. The journal has a strong scientific and medical focus, but also strives to serve a broader readership. The articles are thus of interest to scientists, clinical researchers, and physicians, as well as the wider mAb community, including our readers involved in technology transfer, legal issues, investment, strategic planning and the regulation of therapeutics.
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