Risk factors for mild cognitive impairment in Parkinson disease: a systematic review and meta-analysis.

IF 3.7 2区 生物学 Q3 CELL BIOLOGY
Yaodan Zhang, Fang Chen, Fengchun Ren
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Abstract

Background: Mild cognitive impairment (MCI) is a common non-motor manifestation of Parkinson's disease (PD) and often precedes dementia. However, evidence on its demographic and clinical risk factors remains inconsistent. This study aimed to synthesize available data through a meta-analysis to identify determinants of MCI in PD.

Methodology: This systematic review and meta-analysis followed PRISMA guidelines. Electronic databases were searched using MeSH terms and validated keywords. Studies were selected through a multi-step screening process by independent reviewers. Data extraction and quality assessment were performed using the Newcastle-Ottawa Scale. Meta-analyses were conducted using Comprehensive Meta-Analysis (v2). Random- or fixed-effects models were applied based on heterogeneity (I2 threshold = 50%). Beggs and Mazumdar test assessed publication bias, with significance set at (P < 0.1).

Results: This meta-analysis included 33 studies, Significant risk factors for MCI in individuals with PD included older age (effect size = 0.4, 95% CI: 0.315-0.498, P ≤ 0.001), older age at disease onset (effect size = 0.18, 95% CI: 0.05-0.327, P ≤ 0.001), and longer disease duration (effect size = 0.14, 95% CI: 0.08-0.2, P ≤ 0.001). Higher educational attainment showed a protective effect (effect size = -0.438, 95% CI: -0.555 to -0.321, P ≤ 0.001). No significant association was found between gender and MCI (OR = 0.899, 95% CI: 0.749-1.079, P = 0.253). Disease severity, based on UPDRS and Hoehn and Yahr scales, was significantly associated with increased MCI risk.

Conclusion: Advanced age, later disease onset, longer disease duration, and greater severity are key risk factors for MCI in PD. These findings highlight the need for early detection and proactive management to guide clinical decisions.

帕金森病轻度认知障碍的危险因素:系统回顾和荟萃分析
背景:轻度认知障碍(MCI)是帕金森病(PD)常见的非运动表现,常先于痴呆。然而,关于其人口学和临床危险因素的证据仍然不一致。本研究旨在通过荟萃分析综合现有数据,以确定PD中MCI的决定因素。方法:本系统综述和荟萃分析遵循PRISMA指南。使用MeSH术语和验证过的关键词检索电子数据库。研究是由独立审稿人通过多步骤筛选过程选择的。使用纽卡斯尔-渥太华量表进行数据提取和质量评估。采用综合元分析(Comprehensive Meta-Analysis, v2)进行meta分析。基于异质性(I2阈值= 50%)应用随机或固定效应模型。Beggs和Mazumdar检验评估了发表偏倚,显著性设置为(P)结果:该荟萃分析包括33项研究,PD患者MCI的显著危险因素包括年龄较大(效应值= 0.4,95% CI: 0.315-0.498, P≤0.001)、发病年龄较大(效应值= 0.18,95% CI: 0.05-0.327, P≤0.001)和病程较长(效应值= 0.14,95% CI: 0.08-0.2, P≤0.001)。较高的受教育程度显示出保护作用(效应值= -0.438,95% CI: -0.555 ~ -0.321, P≤0.001)。性别与MCI无显著相关性(OR = 0.899, 95% CI: 0.749 ~ 1.079, P = 0.253)。基于UPDRS和Hoehn和Yahr量表的疾病严重程度与MCI风险增加显著相关。结论:高龄、发病晚、病程长、严重程度高是PD患者发生MCI的关键危险因素。这些发现强调了早期发现和积极管理的必要性,以指导临床决策。
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来源期刊
Molecular and Cellular Biochemistry
Molecular and Cellular Biochemistry 生物-细胞生物学
CiteScore
8.30
自引率
2.30%
发文量
293
审稿时长
1.7 months
期刊介绍: Molecular and Cellular Biochemistry: An International Journal for Chemical Biology in Health and Disease publishes original research papers and short communications in all areas of the biochemical sciences, emphasizing novel findings relevant to the biochemical basis of cellular function and disease processes, as well as the mechanics of action of hormones and chemical agents. Coverage includes membrane transport, receptor mechanism, immune response, secretory processes, and cytoskeletal function, as well as biochemical structure-function relationships in the cell. In addition to the reports of original research, the journal publishes state of the art reviews. Specific subjects covered by Molecular and Cellular Biochemistry include cellular metabolism, cellular pathophysiology, enzymology, ion transport, lipid biochemistry, membrane biochemistry, molecular biology, nuclear structure and function, and protein chemistry.
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