Prevalence, characteristics, and screening of spondyloarthritis in Japanese patients with early inflammatory bowel diseases: a prospective multidisciplinary study.

IF 5.5 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Sho Fukui, Mitsumasa Kishimoto, Minoru Matsuura, Aika Sakamoto, Keisuke Ono, Satoshi Kobayashi, Soko Kawashima, Noriko Ikegaya, Takahisa Kawakami, Tatsuya Mitsui, Daisuke Saito, Mari Hayashida, Jun Miyoshi, Yoshinori Komagata, Tadakazu Hisamatsu
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引用次数: 0

Abstract

Background: The prevalence and characteristics of inflammatory bowel disease-associated spondyloarthritis (IBD-SpA) in Japan are unclear. Moreover, methods for screening SpA among IBD patients have not been established.

Methods: This single-center prospective multidisciplinary study included consecutive patients with IBD, which was newly diagnosed within the past 3 years (early IBD). Board-certified rheumatologists examined the patients for disease history and musculoskeletal manifestations, with imaging studies if needed. Questionnaires assessed patient-reported outcomes and Psoriatic Arthritis Screening and Evaluation (PASE) scores.

Results: We identified 85 eligible patients with early IBD, 22 (25.9%) of whom had Crohn's disease, 63 (74.1%) had ulcerative colitis, and 3 (3.5%) had IBD-SpA diagnosed prior to study enrollment. Rheumatologist evaluations identified additional seven SpA cases, resulting in a total of 10 patients (11.8%) with IBD-SpA (1: axial, 9: peripheral). IBD patients without SpA often presented with back pain (52%) and peripheral joint pain (24%), whereas arthritis, cervical and thoracic pain, and inflammatory back pain were more frequent in IBD-SpA. Newly identified IBD-SpA cases tended to have lower-limb arthritis, dactylitis, and enthesitis, compared with previously diagnosed IBD-SpA cases. For patients with active SpA symptoms in the past 6 months, PASE demonstrated that the area under the receiver operating characteristic curve was 0.87 (95% confidence interval: 0.68, 1.00). The optimal cut-off (33 points) had a sensitivity of 0.88 and specificity of 0.88.

Conclusions: This prospective study found rheumatologist evaluation increased SpA diagnosis and 11.8% of Japanese early IBD patients had IBD-SpA. PASE questionnaires may be effective for screening SpA among IBD patients.

日本早期炎症性肠病患者脊柱炎的患病率、特征和筛查:一项前瞻性多学科研究
背景:日本炎症性肠病相关性脊柱炎(IBD-SpA)的患病率和特征尚不清楚。此外,在IBD患者中筛查SpA的方法尚未建立。方法:这项单中心前瞻性多学科研究纳入了连续3年内新诊断的IBD患者(早期IBD)。经委员会认证的风湿病学家检查患者的病史和肌肉骨骼表现,必要时进行影像学检查。问卷评估了患者报告的结果和银屑病关节炎筛查和评估(PASE)评分。结果:我们确定了85例符合条件的早期IBD患者,其中22例(25.9%)患有克罗恩病,63例(74.1%)患有溃疡性结肠炎,3例(3.5%)在研究入组前诊断为IBD- spa。风湿病学家评估发现了另外7例SpA病例,总共有10例(11.8%)患者患有IBD-SpA(1例:轴向,9例:外周)。没有SpA的IBD患者通常表现为背部疼痛(52%)和周围关节疼痛(24%),而关节炎、颈椎和胸椎疼痛以及炎症性背部疼痛在IBD-SpA患者中更为常见。与先前诊断的IBD-SpA病例相比,新发现的IBD-SpA病例往往患有下肢关节炎、指炎和鼻炎。对于过去6个月有活动性SpA症状的患者,PASE显示,受试者工作特征曲线下面积为0.87(95%可信区间:0.68,1.00)。最佳临界值(33点)的敏感性为0.88,特异性为0.88。结论:这项前瞻性研究发现风湿病学家的评估增加了SpA诊断,11.8%的日本早期IBD患者有IBD-SpA。PASE问卷可能对IBD患者的SpA筛查有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Gastroenterology
Journal of Gastroenterology 医学-胃肠肝病学
CiteScore
12.20
自引率
1.60%
发文量
99
审稿时长
4-8 weeks
期刊介绍: The Journal of Gastroenterology, which is the official publication of the Japanese Society of Gastroenterology, publishes Original Articles (Alimentary Tract/Liver, Pancreas, and Biliary Tract), Review Articles, Letters to the Editors and other articles on all aspects of the field of gastroenterology. Significant contributions relating to basic research, theory, and practice are welcomed. These publications are designed to disseminate knowledge in this field to a worldwide audience, and accordingly, its editorial board has an international membership.
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