Comparative evaluation of β-glucan functional dressing and interferon-α2a plug for vaginal microecology restoration and HPV clearance in women with bacterial vaginosis or aerobic vaginitis.

IF 0.9 Q4 ONCOLOGY
International journal of clinical and experimental pathology Pub Date : 2025-08-15 eCollection Date: 2025-01-01 DOI:10.62347/ZLJW5581
Yuyan Dong, Fang Han, Hui Zhang
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引用次数: 0

Abstract

Objective: To compare the effectiveness of β-glucan functional dressing and interferon-α2a (IFN-α2a) plug in promoting high-risk human papillomavirus (HR-HPV) clearance and restoring vaginal microecology in women with bacterial vaginosis (BV) or aerobic vaginitis (AV).

Methods: This prospective-retrospective study enrolled 44 women diagnosed with BV or AV. Participants were evaluated for vaginal ecological indicators including pH, cleanliness, hydrogen peroxide (H2O2), sialidase, leukocyte esterase (LE), microbial diversity, lactobacilli proportion, and standard diagnostic scores (Nugent and AV). HPV status and squamous intraepithelial lesion (SIL) grade were assessed via cytology and colposcopy. Subjects were randomly divided into Group A (n=22), treated with β-glucan dressing, and Group B (n=22), treated with IFN-α2a plug for 14 days (excluding menstruation). Clinical and virological parameters were re-evaluated after three months.

Results: Both groups were comparable at baseline. No adverse effects were reported. Post-treatment analysis showed that β-glucan dressing significantly improved markers of inflammation (LE, H2O2), increased lactobacilli abundance, and reduced pathogenic bacteria. IFN-α2a treatment improved vaginal pH and diagnostic scores but was less effective in microbiota restoration. The HPV-negative conversion rate was higher in the β-glucan group (87%) than that in the IFN-α2a group, and the difference was statistically significant (P<0.05).

Conclusion: Both β-glucan and IFN-α2a dressings were safe and showed clinical benefits in women with BV or AV and HR-HPV infection. However, β-glucan demonstrated superior outcomes in restoring vaginal microecology and enhancing HPV clearance. These findings suggest that β-glucan may serve as a more effective intravaginal immunomodulatory therapy. Further multicenter studies with larger samples are needed to confirm these results.

β-葡聚糖功能敷料与干扰素-α2a塞对细菌性阴道病或需氧性阴道炎患者阴道微生态修复及HPV清除效果的比较评价
目的:比较β-葡聚糖功能换药与干扰素-α2a (IFN-α2a)塞在促进细菌性阴道病(BV)或需氧性阴道炎(AV)患者高危人乳头瘤病毒(HR-HPV)清除和恢复阴道微生态方面的效果。方法:这项前瞻性-回顾性研究纳入了44名诊断为BV或AV的女性。对参与者进行阴道生态指标评估,包括pH值、洁净度、过氧化氢(H2O2)、唾液酸酶、白细胞酯酶(LE)、微生物多样性、乳酸菌比例和标准诊断评分(Nugent和AV)。通过细胞学和阴道镜检查评估HPV状态和鳞状上皮内病变(SIL)等级。随机分为A组(n=22)和B组(n=22), A组采用β-葡聚糖敷料治疗,B组采用IFN-α2a堵塞治疗,疗程14 d(不含月经)。3个月后重新评估临床和病毒学参数。结果:两组在基线时具有可比性。无不良反应报告。治疗后分析显示,β-葡聚糖敷料显著改善炎症标志物(LE, H2O2),增加乳酸菌丰度,减少致病菌。IFN-α2a治疗改善了阴道pH值和诊断评分,但在微生物群恢复方面效果较差。β-葡聚糖组hpv阴性转换率(87%)高于IFN-α2a组,差异有统计学意义(p)结论:β-葡聚糖和IFN-α2a敷料对BV或AV合并HR-HPV感染的女性是安全的,且具有临床疗效。然而,β-葡聚糖在恢复阴道微生态和增强HPV清除方面表现出优越的结果。这些发现表明β-葡聚糖可能作为一种更有效的阴道内免疫调节疗法。需要更多的多中心研究来证实这些结果。
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来源期刊
自引率
0.00%
发文量
42
审稿时长
1 months
期刊介绍: The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.
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