Comparative evaluation of β-glucan functional dressing and interferon-α2a plug for vaginal microecology restoration and HPV clearance in women with bacterial vaginosis or aerobic vaginitis.
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引用次数: 0
Abstract
Objective: To compare the effectiveness of β-glucan functional dressing and interferon-α2a (IFN-α2a) plug in promoting high-risk human papillomavirus (HR-HPV) clearance and restoring vaginal microecology in women with bacterial vaginosis (BV) or aerobic vaginitis (AV).
Methods: This prospective-retrospective study enrolled 44 women diagnosed with BV or AV. Participants were evaluated for vaginal ecological indicators including pH, cleanliness, hydrogen peroxide (H2O2), sialidase, leukocyte esterase (LE), microbial diversity, lactobacilli proportion, and standard diagnostic scores (Nugent and AV). HPV status and squamous intraepithelial lesion (SIL) grade were assessed via cytology and colposcopy. Subjects were randomly divided into Group A (n=22), treated with β-glucan dressing, and Group B (n=22), treated with IFN-α2a plug for 14 days (excluding menstruation). Clinical and virological parameters were re-evaluated after three months.
Results: Both groups were comparable at baseline. No adverse effects were reported. Post-treatment analysis showed that β-glucan dressing significantly improved markers of inflammation (LE, H2O2), increased lactobacilli abundance, and reduced pathogenic bacteria. IFN-α2a treatment improved vaginal pH and diagnostic scores but was less effective in microbiota restoration. The HPV-negative conversion rate was higher in the β-glucan group (87%) than that in the IFN-α2a group, and the difference was statistically significant (P<0.05).
Conclusion: Both β-glucan and IFN-α2a dressings were safe and showed clinical benefits in women with BV or AV and HR-HPV infection. However, β-glucan demonstrated superior outcomes in restoring vaginal microecology and enhancing HPV clearance. These findings suggest that β-glucan may serve as a more effective intravaginal immunomodulatory therapy. Further multicenter studies with larger samples are needed to confirm these results.
期刊介绍:
The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.