Therapeutic Potential of Scorpion Venom Proteins: Innovations in Cancer Treatment and Future Directions.

IF 2.5 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current drug targets Pub Date : 2025-09-16 DOI:10.2174/0113894501396738250904071722

Nooshin Ghadiri, Vida Homayouni, Zahra Akbari Jonoush, Roya Mahdavi, Nastaran Mohammadi, Amir Mohamad Amiri, Mahdieh Sadat Badiee, Mazdak Ganjalikhani Hakemi

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引用次数: 0

Abstract

Cancer is a significant human health concern due to its increasing mortality rate and profound impact on public health and healthcare systems. The cytotoxic, antiproliferative, immunosuppressive, and apoptogenic properties of scorpion venom proteins and peptides have been observed in various cancer cell lines. Therefore, the purpose of this study was to investigate the potential use of proteins derived from scorpion venom in cancer treatment. In this study, the effects of different scorpion venoms on transmembrane channels, the inhibition of angiogenesis, the inhibition of invasion and metastasis, the inhibition of proliferation, and the induction of apoptosis were investigated, as were their clinical applications in the treatment of hepatocellular carcinoma and breast, cervical, prostate, colorectal, and melanoma cancers. The results showed that various scorpion venoms can suppress cell growth, stimulate apoptosis, reduce tumor size, and enhance the immune response, thereby serving as alternative drugs for treating various types of cancers and their metastasis. This review suggests a positive association between scorpion venom (SV) proteins and the treatment of these cancers. Future research should focus on understanding the underlying mechanisms, identifying biomarkers to predict response, and exploring potential combination therapies to increase the efficacy of scorpion venom proteins in cancer treatment.

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蝎毒蛋白的治疗潜力：癌症治疗的创新和未来方向。

癌症因其不断上升的死亡率和对公共卫生和医疗保健系统的深远影响而成为一个重大的人类健康问题。蝎毒蛋白和肽的细胞毒性、抗增殖、免疫抑制和致凋亡特性已在多种癌细胞系中被观察到。因此，本研究的目的是探讨从蝎子毒液中提取的蛋白质在癌症治疗中的潜在用途。本研究探讨了不同蝎子毒液对跨膜通道的影响、对血管生成的抑制、对侵袭转移的抑制、对增殖的抑制和对细胞凋亡的诱导，以及它们在肝癌、乳腺癌、宫颈癌、前列腺癌、结直肠癌和黑色素瘤中的临床应用。结果表明，多种蝎子毒液具有抑制细胞生长、刺激细胞凋亡、缩小肿瘤大小、增强免疫应答等作用，可作为治疗多种类型癌症及其转移的替代药物。这一综述表明蝎子毒液（SV）蛋白与这些癌症的治疗之间存在正相关。未来的研究应侧重于了解其潜在机制，识别生物标志物以预测反应，并探索潜在的联合治疗方法以提高蝎子毒液蛋白在癌症治疗中的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug targets 医学-药学

CiteScore

6.20

自引率

0.00%

发文量

127

审稿时长

3-8 weeks

期刊介绍： Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication mini- & full-length review articles and drug clinical trial studies. As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.