Pulmonary nontuberculous mycobacteria disease and anti-neutrophil cytoplasmic antibody positivity: a retrospective analysis of long-term clinical outcomes including vasculitis onset.

IF 3.4 4区 医学 Q2 RHEUMATOLOGY
Nobuhiro Oda, Hiroki Matsui, Naoki Oya, Tomo Suzuki, Ryo Hazue, Ryo Rokutanda
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引用次数: 0

Abstract

Objectives: To investigate the positivity rate of anti-neutrophil cytoplasmic antibody (ANCA) and the incidence of ANCA-associated vasculitis (AAV) in pulmonary nontuberculous mycobacterial (NTM) disease.

Methods: We conducted a retrospective observational study using electronic medical records of patients diagnosed with pulmonary NTM disease who subsequently underwent testing for myeloperoxidase (MPO) or proteinase 3 (PR3) ANCA. We identified cases of vasculitis among these patients and documented those who developed AAV. Additionally, we reviewed the literature for previously reported cases of AAV following pulmonary NTM disease.

Results: We identified 63 patients with pulmonary NTM disease who subsequently underwent ANCA testing. Seven cases (11.1%) tested positive, predominantly for MPO-ANCA. Among them, five patients (71.4%) developed AAV, with three demonstrating concurrent NTM culture positivity at the time of AAV diagnosis. Three patients were diagnosed with microscopic polyangiitis, while the remaining two were diagnosed with granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis, respectively. In our case series of AAV, most patients developed glomerulonephritis. Additionally, a review of the existing literature revealed eight previously reported cases of AAV associated with pulmonary NTM disease.

Conclusions: This study is one of the largest to investigate the proportion of patients positive for ANCA with pulmonary NTM infection. Our findings suggest an association between NTM infection and AAV and highlight the importance of measuring ANCA in patients with NTM. Further studies are needed to clarify the underlying mechanisms and identify risk factors.

肺非结核分枝杆菌病和抗中性粒细胞细胞质抗体阳性:包括血管炎发病的长期临床结果的回顾性分析
目的:探讨抗中性粒细胞胞浆抗体(ANCA)在肺非结核分枝杆菌病(NTM)中的阳性率及ANCA相关性血管炎(AAV)的发生率。方法:我们对诊断为肺NTM疾病的患者的电子病历进行了回顾性观察研究,这些患者随后接受了髓过氧化物酶(MPO)或蛋白酶3 (PR3) ANCA检测。我们在这些患者中确定了血管炎病例,并记录了那些发展为AAV的病例。此外,我们回顾了先前报道的肺NTM疾病后AAV病例的文献。结果:我们确定了63例肺部NTM疾病患者,他们随后接受了ANCA检测。7例(11.1%)检测呈阳性,主要为MPO-ANCA。其中5例(71.4%)发生AAV,其中3例在AAV诊断时并发NTM培养阳性。3例诊断为镜下多血管炎,2例诊断为肉芽肿病合并多血管炎和嗜酸性肉芽肿病合并多血管炎。在我们的AAV病例系列中,大多数患者发展为肾小球肾炎。此外,对现有文献的回顾揭示了8例先前报道的与肺NTM疾病相关的AAV病例。结论:本研究是调查ANCA阳性患者肺部NTM感染比例最大的研究之一。我们的研究结果表明NTM感染与AAV之间存在关联,并强调了在NTM患者中测量ANCA的重要性。需要进一步的研究来阐明潜在的机制和确定风险因素。
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来源期刊
CiteScore
6.10
自引率
18.90%
发文量
377
审稿时长
3-6 weeks
期刊介绍: Clinical and Experimental Rheumatology is a bi-monthly international peer-reviewed journal which has been covering all clinical, experimental and translational aspects of musculoskeletal, arthritic and connective tissue diseases since 1983.
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