Exploring the Therapeutic Potential of Plant-Based Natural Products in Combating Aging.

IF 2.5 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current drug targets Pub Date : 2025-09-16 DOI:10.2174/0113894501384653250903110249

Adarsh Sharma, Arya Ojha, Sunny Rathee, Sanjay K Jain, Umesh K Patil

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Abstract

Aging is a complex biological process marked by progressive cellular and tissue decline, leading to an increased risk of age-related diseases. Plant-based natural compounds, including polyphenols, flavonoids, carotenoids, alkaloids, and terpenoids, have gained attention for their potential in mitigating aging-related damage through antioxidant, anti-inflammatory, and cellular repair mechanisms. The review identified that plant-derived bioactive compounds target key pathways involved in aging, including Sirtuins (SIRT1), AMP-activated protein kinase (AMPK), and Nuclear Factor-kappa B (NF-κB). These compounds address key hallmarks of aging, such as oxidative stress, mitochondrial dysfunction, cellular senescence, and chronic inflammation. Evidence suggests their potential in preventing or delaying age-related disorders, including neurodegenerative diseases, cardiovascular conditions, and skin aging. Plant-derived compounds offer a promising alternative to synthetic anti-aging interventions due to their efficacy, safety, and sustainability. However, challenges such as low bioavailability and limited clinical validation must be addressed. Advances in drug delivery systems and comprehensive clinical trials are critical to realizing their full therapeutic potential. Plant-based bioactive compounds represent a significant opportunity for developing safer and more sustainable anti-aging therapies. Continued research is essential to overcome existing limitations and facilitate the integration of these approaches into mainstream healthcare practices.

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探索植物性天然产物抗衰老的治疗潜力。

衰老是一个复杂的生物过程，其标志是细胞和组织的进行性衰退，导致与年龄有关的疾病的风险增加。以植物为基础的天然化合物，包括多酚、类黄酮、类胡萝卜素、生物碱和萜类化合物，因其通过抗氧化、抗炎和细胞修复机制减轻衰老相关损伤的潜力而受到关注。综述发现，植物源性生物活性化合物靶向衰老的关键途径，包括Sirtuins （SIRT1）、amp活化蛋白激酶（AMPK）和核因子κB （NF-κB）。这些化合物解决了衰老的关键特征，如氧化应激、线粒体功能障碍、细胞衰老和慢性炎症。有证据表明，它们有可能预防或延缓与年龄有关的疾病，包括神经退行性疾病、心血管疾病和皮肤老化。植物源性化合物由于其有效性、安全性和可持续性，为合成抗衰老干预措施提供了一个有希望的替代方案。然而，诸如低生物利用度和有限的临床验证等挑战必须得到解决。药物输送系统的进步和全面的临床试验对于充分发挥其治疗潜力至关重要。基于植物的生物活性化合物为开发更安全、更可持续的抗衰老疗法提供了重要机会。持续的研究对于克服现有的限制和促进将这些方法整合到主流医疗保健实践中至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug targets 医学-药学

CiteScore

6.20

自引率

0.00%

发文量

127

审稿时长

3-8 weeks

期刊介绍： Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes. Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication mini- & full-length review articles and drug clinical trial studies. As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.