Association of visceral adipose tissue with inflammation and functional impairment in women with Sjögren's disease.

IF 3.4 4区 医学 Q2 RHEUMATOLOGY
Andre S Franco, Igor H Murai, Thomas H Yang, Virginia L N Bonoldi, Valeria de Falco Caparbo, Lissiane Guedes, Diogo S Domiciano, Sandra G Pasoto, Camille P Figueiredo, Rosa M R Pereira
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Abstract

Objectives: This study aimed to evaluate the association between visceral adipose tissue (VAT) levels and inflammation, disease activity, and functional impairment in women with primary Sjögren's Disease (SjD).

Methods: We included 100 female patients with SjD from a tertiary care clinic who met the ACR/EULAR 2016 classification criteria. Disease activity was assessed using the ESSDAI and ESSPRI scores, while cumulative damage was evaluated by the SSDI. Inflammatory markers, synovitis (via ultrasound), and functional disability using the HAQ were measured. Body composition, including VAT, was analysed using dual-energy X-ray absorptiometry. Handgrip strength and physical activity (Baecke questionnaire) were also assessed. Patients were categorised into VAT tertiles, and comparisons were made to healthy controls. Correlations between VAT, disease activity, and synovitis were analysed using multiple regression models.

Results: The patients had a mean age of 50.5±9.3 years, BMI of 28.2±5.6 kg/m², and median disease duration of 8 years. The highest VAT tertile was associated with a higher prevalence of synovitis (75.7% vs. 51.5%; p=0.041), lower handgrip strength (p=0.025), and higher HAQ scores (p<0.001). VAT mass was significantly correlated with obesity (p<0.001), functional disability (p=0.002), and ESSPRI (p=0.01). Postmenopausal patients had significantly higher VAT levels than premenopausal patients (p=0.005). There were no significant correlations between VAT and inflammation.

Conclusions: Elevated VAT levels in SjD are associated with increased disease activity, a higher prevalence of synovitis, and greater functional disability, suggesting that VAT may contribute to the functional impairment observed in SjD.

女性Sjögren病患者内脏脂肪组织与炎症和功能损害的关系
目的:本研究旨在评估女性原发性Sjögren's disease (SjD)患者的内脏脂肪组织(VAT)水平与炎症、疾病活动性和功能损害之间的关系。方法:我们纳入了100名来自三级保健诊所的女性SjD患者,符合ACR/EULAR 2016分类标准。使用ESSDAI和ESSPRI评分评估疾病活动性,而使用SSDI评估累积损害。使用HAQ测量炎症标志物、滑膜炎(通过超声)和功能残疾。使用双能x射线吸收仪分析身体成分,包括VAT。握力和体力活动(Baecke问卷)也进行了评估。将患者分为VAT组,并与健康对照进行比较。使用多元回归模型分析VAT、疾病活动性和滑膜炎之间的相关性。结果:患者平均年龄50.5±9.3岁,BMI 28.2±5.6 kg/m²,中位病程8年。VAT值越高,滑膜炎患病率越高(75.7% vs. 51.5%, p=0.041),握力越低(p=0.025), HAQ评分越高(p= 0.041)。结论:SjD中VAT值升高与疾病活动度增加、滑膜炎患病率升高和功能残疾程度加重相关,提示VAT可能导致SjD中观察到的功能损伤。
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来源期刊
CiteScore
6.10
自引率
18.90%
发文量
377
审稿时长
3-6 weeks
期刊介绍: Clinical and Experimental Rheumatology is a bi-monthly international peer-reviewed journal which has been covering all clinical, experimental and translational aspects of musculoskeletal, arthritic and connective tissue diseases since 1983.
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