Psychedelics for major depression-From controlled research settings into broader clinical use.

IF 10.6 1区医学 Q1 CELL BIOLOGY

Cell Reports Medicine Pub Date : 2025-09-16 DOI:10.1016/j.xcrm.2025.102361

Mihai Avram, Stefan Borgwardt

引用次数: 0

Abstract

Psychedelics have shown promising antidepressant effects in recent phase 2 randomized controlled trials, with phase 3 studies underway. While therapeutic outcomes are encouraging, the underlying mechanisms-from receptor-level pharmacology to subjective experience and context-remain only partially understood. We highlight clinical and mechanistic advances and outline priorities for future research.

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重度抑郁症的致幻剂——从受控研究环境到更广泛的临床应用。

在最近的2期随机对照试验中，致幻剂显示出有希望的抗抑郁作用，3期研究正在进行中。虽然治疗结果令人鼓舞，但潜在的机制——从受体水平的药理学到主观体验和环境——仍然只是部分被理解。我们强调临床和机械方面的进展，并概述未来研究的重点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Reports Medicine Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

15.00

自引率

1.40%

发文量

231

审稿时长

40 days

期刊介绍： Cell Reports Medicine is an esteemed open-access journal by Cell Press that publishes groundbreaking research in translational and clinical biomedical sciences, influencing human health and medicine. Our journal ensures wide visibility and accessibility, reaching scientists and clinicians across various medical disciplines. We publish original research that spans from intriguing human biology concepts to all aspects of clinical work. We encourage submissions that introduce innovative ideas, forging new paths in clinical research and practice. We also welcome studies that provide vital information, enhancing our understanding of current standards of care in diagnosis, treatment, and prognosis. This encompasses translational studies, clinical trials (including long-term follow-ups), genomics, biomarker discovery, and technological advancements that contribute to diagnostics, treatment, and healthcare. Additionally, studies based on vertebrate model organisms are within the scope of the journal, as long as they directly relate to human health and disease.