Radical Addition-Induced Dearomative Spirocyclization/1,4-Alkyloximation of Unactivated Arenes

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-09-18 DOI:10.1021/acs.orglett.5c03231

Cong Shi, , , Ruihua Liu*, , , Chao Xie, , , Zemin Wang, , , Yuanyuan Zhao, , , Hongyun Qin, , , Jia-Shu Chen, , , Chao Liu, , , Nan Zhou, , , Yue Xu, , , Xiangqian Li, , and , Dayong Shi*,

引用次数: 0

Abstract

Nitrogenated spirocycles, as integral structural cores of numerous bioactive molecules, are valuable yet synthetically challenging three-dimensional scaffolds. Herein, we report a radical addition-induced dearomative spirocyclization/1,4-alkyloximation of unactivated arenes. The multicomponent protocol concurrently breaks the stable aromatic system and introduces multiple functional groups to synthesize highly decorated nitrogenated spirocycles via a radical cascade process.

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自由基加成诱导非活化芳烃的去芳香螺旋环化/1,4-烷基化。

氮化螺旋环作为众多生物活性分子的整体结构核心，是一种有价值但具有合成挑战性的三维支架。在此，我们报道了自由基加成诱导的非活化芳烃的去芳香螺旋环化/1,4-烷基化。多组分方案同时打破稳定的芳香体系，引入多个官能团，通过自由基级联工艺合成高修饰的氮化螺环。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.