Enhancing home oxygen therapy: automation to facilitate ambulation

IF 7.7 1区 医学 Q1 RESPIRATORY SYSTEM
Thorax Pub Date : 2025-09-17 DOI:10.1136/thorax-2025-223695
Richard D Branson
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引用次数: 0

Abstract

Long-term oxygen therapy (LTOT) is provided in the home for patients with chronic obstructive pulmonary disease (COPD) who present with resting hypoxaemia (SpO2 <88%, PaO2 <60 mm Hg (8 kPa)). In the USA, LTOT is provided to approximately 1.5 million adults at an annual cost of ~$2 billion.1 The evidence base for LTOT remains two landmark studies from four decades ago, demonstrating an apparent dose–response relationship between the daily duration of therapy and mortality.2 3 LTOT is commonly referred to as ‘home’ oxygen therapy which belies the fact that while the modality is provided in the home, the intent is to allow subjects mobility, a return to a more active life and travel outside the home.4 Patients express a desire to be mobile and participate in activities of daily living (ADL).5 Activities, however, are often limited by fatigue, hypoxaemia and dyspnoea. In addition, portable oxygen systems may limit activity owing to insufficient flow, short duration of supply, constant output and portability.4 5 The goals of increased ambulation, however, have to be balanced against the findings that LTOT for moderate exertional hypoxaemia fails to impart a mortality or other patient-important benefit.6 In this issue …
加强家庭氧疗:自动化,方便行走
慢性阻塞性肺疾病(COPD)患者静息低氧血症(SpO2 <88%, PaO2 <60 mm Hg (8 kPa))在家中提供长期氧疗(LTOT)。在美国,每年约有150万成年人享受ltt服务,费用约为20亿美元LTOT的证据基础仍然是40年前的两项具有里程碑意义的研究,表明每日治疗持续时间与死亡率之间存在明显的剂量-反应关系。LTOT通常被称为“家庭”氧疗,它掩盖了这样一个事实,即虽然这种方式是在家中提供的,但其目的是允许受试者移动,回到更活跃的生活和外出旅行患者表现出移动和参与日常生活活动(ADL)的愿望然而,活动经常受到疲劳、低氧血症和呼吸困难的限制。此外,便携式供氧系统可能由于流量不足、供应时间短、输出恒定和便携性而限制活动。然而,增加活动的目标必须与以下发现相平衡:中度运动性低氧血症的lot不能带来死亡率或其他对患者重要的益处在本期中……
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来源期刊
Thorax
Thorax 医学-呼吸系统
CiteScore
16.10
自引率
2.00%
发文量
197
审稿时长
1 months
期刊介绍: Thorax stands as one of the premier respiratory medicine journals globally, featuring clinical and experimental research articles spanning respiratory medicine, pediatrics, immunology, pharmacology, pathology, and surgery. The journal's mission is to publish noteworthy advancements in scientific understanding that are poised to influence clinical practice significantly. This encompasses articles delving into basic and translational mechanisms applicable to clinical material, covering areas such as cell and molecular biology, genetics, epidemiology, and immunology.
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