Dietary Diabetes Risk Reduction Score (DDRRS) and the Risk of Colorectal Cancer and Adenoma: A Case-Control Study.

IF 3.2

Clinical colorectal cancer Pub Date : 2025-08-20 DOI:10.1016/j.clcc.2025.08.006

Niayesh Naghshi, Milad Mohammadzadeh, Fatemeh Babaee Kiadehi, Alireza Bahrami, Fatemeh Abdi, Mohammad Gholizadeh, Ehsan Hejazi

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Abstract

Background: Given the role of insulin resistance in several cancers, we hypothesized that the risk of colorectal cancer and colorectal adenoma may be lessened by following a diet that improves insulin resistance. Therefore, we conducted the current study to examine the association between dietary diabetes risk reduction and the odds of colorectal cancer and colorectal adenoma.

Method: This hospital-based case-control study was conducted on 129 newly diagnosed colorectal cancer patients, 130 newly diagnosed colorectal adenoma cases, and 240 healthy age- and sex-matched hospitalized controls. We used a valid and reliable 148-item food frequency questionnaire (FFQ) to collect the dietary intake of subjects. Multivariate logistic regression was used to estimate the association between DDRRS and the odds of colorectal cancer and adenoma.

Results: After adjusting for confounding variables, individuals in the highest tertile of the DDRRS were 0.13 and 0.22 times less likely to have colorectal cancer (OR = 0.13, 95% CI: 0.06-0.25) and adenoma (OR = 0.22, 95% CI: 0.12-0.41) respectively.

Conclusion: Current results demonstrated that a high DDRRS was associated with a lower risk of colorectal cancer and adenoma.

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饮食糖尿病风险降低评分（DDRRS）与结直肠癌和腺瘤的风险：一项病例对照研究

背景：鉴于胰岛素抵抗在几种癌症中的作用，我们假设遵循改善胰岛素抵抗的饮食可能会降低结直肠癌和结直肠腺瘤的风险。因此，我们进行了当前的研究，以检查饮食糖尿病风险降低与结直肠癌和结直肠腺瘤发病率之间的关系。方法：以医院为基础的病例对照研究，选取129例新诊断的结直肠癌患者、130例新诊断的结直肠腺瘤患者和240例年龄、性别匹配的健康住院对照。我们采用一份有效可靠的148项食物频率问卷（FFQ）来收集受试者的膳食摄入量。采用多变量logistic回归来估计DDRRS与结直肠癌和腺瘤发生率之间的关系。结果：在调整了混杂变量后，DDRRS中最高五分位数的个体患结直肠癌（OR = 0.13, 95% CI: 0.06-0.25）和腺瘤（OR = 0.22, 95% CI: 0.12-0.41）的可能性分别为0.13和0.22倍。结论：目前的研究结果表明，高DDRRS与结直肠癌和腺瘤的低风险相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical colorectal cancer

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