Shixue Sun, Rosemary Mejia, An N Dang Do, Qian Zhu
{"title":"Identifying Drug Repurposing Candidates for CLN3 Targeting Proteomics Expression Profile.","authors":"Shixue Sun, Rosemary Mejia, An N Dang Do, Qian Zhu","doi":"10.1109/bibm62325.2024.10822002","DOIUrl":null,"url":null,"abstract":"<p><p>Juvenile neuronal ceroid lipofuscinosis (CLN3) is a rare neurodegenerative disorder lacking effective therapies. This study aimed at developing a drug repurposing approach to identify potential therapeutic candidates for CLN3 using its protein expression profile (CPEP) constructed from proteomics data. Differentially expressed proteins were identified and applied to query the iLINCS database, resulting in 60 FDA-approved drugs with reversal effects on CPEP. These candidates were further prioritized based on regulation strength, coverage, and blood-brain barrier permeability. Top candidates include Vorinostat and Cyclosporine, which have shown promise due to their significant regulation scores and blood-brain barrier permeation probability. These results provide opportunities for further investigation on novel therapies for CLN3.</p>","PeriodicalId":74563,"journal":{"name":"Proceedings. IEEE International Conference on Bioinformatics and Biomedicine","volume":"2024 ","pages":"4572-4574"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12434628/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings. IEEE International Conference on Bioinformatics and Biomedicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/bibm62325.2024.10822002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/10 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Juvenile neuronal ceroid lipofuscinosis (CLN3) is a rare neurodegenerative disorder lacking effective therapies. This study aimed at developing a drug repurposing approach to identify potential therapeutic candidates for CLN3 using its protein expression profile (CPEP) constructed from proteomics data. Differentially expressed proteins were identified and applied to query the iLINCS database, resulting in 60 FDA-approved drugs with reversal effects on CPEP. These candidates were further prioritized based on regulation strength, coverage, and blood-brain barrier permeability. Top candidates include Vorinostat and Cyclosporine, which have shown promise due to their significant regulation scores and blood-brain barrier permeation probability. These results provide opportunities for further investigation on novel therapies for CLN3.
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