{"title":"Increasing alignment of large language models with language processing in the human brain.","authors":"Changjiang Gao, Zhengwu Ma, Jiajun Chen, Ping Li, Shujian Huang, Jixing Li","doi":"10.1038/s43588-025-00863-0","DOIUrl":null,"url":null,"abstract":"<p><p>Transformer-based large language models (LLMs) have considerably advanced our understanding of how meaning is represented in the human brain; however, the validity of increasingly large LLMs is being questioned due to their extensive training data and their ability to access context thousands of words long. In this study we investigated whether instruction tuning-another core technique in recent LLMs that goes beyond mere scaling-can enhance models' ability to capture linguistic information in the human brain. We compared base and instruction-tuned LLMs of varying sizes against human behavioral and brain activity measured with eye-tracking and functional magnetic resonance imaging during naturalistic reading. We show that simply making LLMs larger leads to a closer match with the human brain than fine-tuning them with instructions. These finding have substantial implications for understanding the cognitive plausibility of LLMs and their role in studying naturalistic language comprehension.</p>","PeriodicalId":74246,"journal":{"name":"Nature computational science","volume":" ","pages":""},"PeriodicalIF":18.3000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature computational science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s43588-025-00863-0","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS","Score":null,"Total":0}
引用次数: 0
Abstract
Transformer-based large language models (LLMs) have considerably advanced our understanding of how meaning is represented in the human brain; however, the validity of increasingly large LLMs is being questioned due to their extensive training data and their ability to access context thousands of words long. In this study we investigated whether instruction tuning-another core technique in recent LLMs that goes beyond mere scaling-can enhance models' ability to capture linguistic information in the human brain. We compared base and instruction-tuned LLMs of varying sizes against human behavioral and brain activity measured with eye-tracking and functional magnetic resonance imaging during naturalistic reading. We show that simply making LLMs larger leads to a closer match with the human brain than fine-tuning them with instructions. These finding have substantial implications for understanding the cognitive plausibility of LLMs and their role in studying naturalistic language comprehension.