Risk assessment of pneumatic tube systems for in-hospital transportation of biotherapeutics.

IF 0.9 4区 医学 Q4 ONCOLOGY
Michaela Cohrs, Paula E Borgonje, Nele Clottens, Pieter Ramaut, Kevin Braeckmans, Stefaan De Smedt, Hristo L Svilenov, Tiene Bauters
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引用次数: 0

Abstract

IntroductionUse of Pneumatic tube systems (PTS's) poses a risk to inherently unstable protein therapeutics. Mechanical stress caused by those systems can lead to aggregation, compromising product safety and quality. However, PTS's are widely used in hospitals, and contradictory effects on protein stability have been reported.MethodsWe studied whether mechanical stress levels differ between hospitals and routes, potentially leading to different findings regarding protein aggregation. By transporting a mechanical sensor on nine different PTS routes in seven different hospitals, we quantified the accelerations that protein therapeutics experience in a specific PTS setup.ResultsIt was found that the maximum acceleration within the different PTS setups was similar. However, transportation times differed up to 4-fold, leading to varying amounts of cumulative stress.ConclusionThe cumulative and maximum stress quantified can be compared to stress found in studies investigating protein stability, which justifies the usage of mechanical sensors for risk evaluation. The differences in stress found underscore the importance of evaluating handling practices individually in each hospital, for each therapeutic protein.

医院内生物治疗药物输送气动管道系统的风险评估。
使用气动管系统(PTS)会对固有不稳定的蛋白质疗法造成风险。这些系统造成的机械应力会导致聚合,从而影响产品的安全和质量。然而,PTS在医院中广泛使用,对蛋白质稳定性的相互矛盾的影响已被报道。我们研究了机械应力水平在医院和路线之间是否存在差异,这可能导致蛋白质聚集的不同发现。通过在7家不同医院的9条不同PTS路线上运输机械传感器,我们量化了蛋白质疗法在特定PTS设置中所经历的加速度。结果不同PTS设置下的最大加速度是相似的。然而,运输时间相差高达4倍,导致累积应力量不同。结论所量化的累积应力和最大应力可与蛋白质稳定性研究中发现的应力进行比较,证明了使用机械传感器进行风险评估的合理性。所发现的压力差异强调了在每家医院针对每种治疗性蛋白质单独评估处理实践的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.70
自引率
7.70%
发文量
276
期刊介绍: Journal of Oncology Pharmacy Practice is a peer-reviewed scholarly journal dedicated to educating health professionals about providing pharmaceutical care to patients with cancer. It is the official publication of the International Society for Oncology Pharmacy Practitioners (ISOPP). Publishing pertinent case reports and consensus guidelines...
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