Relationship between Meteorin-like protein and type 2 diabetes mellitus: an update and meta-analysis.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Endocrine Connections Pub Date : 2025-09-26 Print Date: 2025-09-01 DOI:10.1530/EC-25-0452

Jing Xie, Yanhua Jiang, Jiayi Yao, Bin Feng, Xin Sun

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引用次数: 0

Abstract

Background: Meteorin-like protein (Metrnl) is considered a novel adipokine, which plays an important role in the occurrence and development of type 2 diabetes mellitus (T2DM). In a previous meta-analysis, no significant difference in circulating Metrnl levels was found between T2DM patients and normal glucose tolerance individuals. However, these meta-analyses included limited studies, and more studies about Metrnl and T2DM were published recently. Therefore, the association between Metrnl and T2DM remains uncertain.

Aim: This study aimed to systematically and comprehensively update the relationship between circulating Metrnl levels and T2DM.

Methods: A systematic search was conducted on the Web of Science, Wiley Online Library, PubMed, and Ovid databases using the terms 'type 2 diabetes mellitus' in combination with 'Metrnl'. Meta-analysis results were reported as standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs).

Results: In total, 17 studies, including 649 patients with T2DM and 396 healthy controls, were included in the meta-analysis. We found that circulating Metrnl levels were lower in patients with T2DM than in healthy individuals (SMD: -0.47, 95% CI: (-0.98, 0.05); prediction interval: (-3.66, 2.73)). Moreover, serum Metrnl levels in patients with T2DM were significantly lower than in healthy individuals (SMD: -0.91, 95% CI: (-1.60, -0.22); prediction interval: (-5.03, 3.21)).

Conclusions: This study aimed to systematically and comprehensively update the relationship between circulating Metrnl levels and T2DM. A clearer understanding of the role of Metrnl in T2DM could facilitate the development of effective treatments.

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流星蛋白样与2型糖尿病的关系：一项最新的meta分析。

背景：流星蛋白样蛋白（Meteorin-like protein, Metrnl）被认为是一种新型的脂肪因子，在2型糖尿病（T2DM）的发生发展中起重要作用。在之前的荟萃分析中，T2DM患者和正常葡萄糖耐量个体之间循环中Metrnl水平没有显著差异。然而，这些荟萃分析包括有限的研究，最近发表了更多关于Metrnl和T2DM的研究。因此，Metrnl与T2DM之间的关系仍不确定。目的：本研究旨在系统、全面地更新循环metnl水平与T2DM之间的关系。方法：系统检索Web of Science、Wiley Online Library、PubMed和Ovid数据库。使用术语“2型糖尿病”与“Metrnl”结合使用。meta分析结果以标准化平均差异（SMD）报告，并具有相应的95%置信区间（CI）。结果：meta分析共纳入17项研究，包括649例T2DM患者和396名健康对照。我们发现T2DM患者的循环Metrnl水平低于健康人（SMD:-0.47, 95% CI[-0.98, 0.05]；预测区间：[-3.66,2.73]）。此外，T2DM患者血清Metrnl水平显著低于健康人（SMD: -0.91, 95% CI[-1.60, -0.22]；预测区间：[-5.03,3.21]）。结论：本研究旨在系统、全面地更新循环metnl水平与T2DM之间的关系。对2型糖尿病中metnl的作用有更清晰的认识有助于开发有效的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Connections Medicine-Internal Medicine

CiteScore

5.00

自引率

3.40%

发文量

361

审稿时长

6 weeks

期刊介绍： Endocrine Connections publishes original quality research and reviews in all areas of endocrinology, including papers that deal with non-classical tissues as source or targets of hormones and endocrine papers that have relevance to endocrine-related and intersecting disciplines and the wider biomedical community.