S. D. Deosarkar, M. P. Pawar, A. D. Arsule, H. N. Pawar
{"title":"Acoustic Properties of Antibacterial Pyridoxine and Neomycin Drugs in Aqueous-Urea Solutions at (T = 303.15, 308.15, and 313.15 K)","authors":"S. D. Deosarkar, M. P. Pawar, A. D. Arsule, H. N. Pawar","doi":"10.1134/S0036024425701754","DOIUrl":null,"url":null,"abstract":"<p>Density, ultrasonic velocity and refractive index of antibacterial pyridoxine hydrochloride (<i>m</i> = 0.02, 0.04, 0.06, 0.08, 0.10, and 0.12 mol kg<sup>–1</sup>) and neomycin sulphate (<i>m</i> = 0.005, 0.02, 0.04, 0.06, 0.08, and 0.10 mol kg<sup>–1</sup>) drugs in aqueous-urea solutions were measured at different temperatures (<i>T</i> = 303.15, 308.15, and 313.15 K). The measured properties were used to calculate derived thermoacoustical properties such as isentropic compressibility, acoustic impedance, intermolecular free length and relative association of different systems. The effect of temperature and co-solute urea concentrations on acoustical properties of studied drugs has been evaluated and interpreted in terms of molecular interactions and structural fittings in drug solutions. The studies have implications in the solubility and bioavailability of studied antibacterial drugs.</p>","PeriodicalId":767,"journal":{"name":"Russian Journal of Physical Chemistry A","volume":"99 9","pages":"2297 - 2306"},"PeriodicalIF":0.8000,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Physical Chemistry A","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S0036024425701754","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Density, ultrasonic velocity and refractive index of antibacterial pyridoxine hydrochloride (m = 0.02, 0.04, 0.06, 0.08, 0.10, and 0.12 mol kg–1) and neomycin sulphate (m = 0.005, 0.02, 0.04, 0.06, 0.08, and 0.10 mol kg–1) drugs in aqueous-urea solutions were measured at different temperatures (T = 303.15, 308.15, and 313.15 K). The measured properties were used to calculate derived thermoacoustical properties such as isentropic compressibility, acoustic impedance, intermolecular free length and relative association of different systems. The effect of temperature and co-solute urea concentrations on acoustical properties of studied drugs has been evaluated and interpreted in terms of molecular interactions and structural fittings in drug solutions. The studies have implications in the solubility and bioavailability of studied antibacterial drugs.
期刊介绍：
Russian Journal of Physical Chemistry A. Focus on Chemistry (Zhurnal Fizicheskoi Khimii), founded in 1930, offers a comprehensive review of theoretical and experimental research from the Russian Academy of Sciences, leading research and academic centers from Russia and from all over the world.
Articles are devoted to chemical thermodynamics and thermochemistry, biophysical chemistry, photochemistry and magnetochemistry, materials structure, quantum chemistry, physical chemistry of nanomaterials and solutions, surface phenomena and adsorption, and methods and techniques of physicochemical studies.
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